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Pyoverdine and PQS mediated subpopulation interactions involved in Pseudomonas aeruginosa biofilm formation.绿脓菌素和2-庚基-3-羟基-4（1H）-喹诺酮介导的亚群相互作用参与铜绿假单胞菌生物膜形成。
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Organization and PprB-dependent control of the Pseudomonas aeruginosa tad Locus, involved in Flp pilus biology.铜绿假单胞菌tad位点的组织及PprB依赖性调控，该位点与Flp菌毛生物学有关。
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Tolerance to the antimicrobial peptide colistin in Pseudomonas aeruginosa biofilms is linked to metabolically active cells, and depends on the pmr and mexAB-oprM genes.铜绿假单胞菌生物膜中对抗菌肽黏菌素的耐受性与代谢活跃细胞有关，且依赖于pmr和mexAB-oprM基因。
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Effects of iron on DNA release and biofilm development by Pseudomonas aeruginosa.铁对铜绿假单胞菌DNA释放及生物膜形成的影响。
Microbiology (Reading). 2007 May;153(Pt 5):1318-1328. doi: 10.1099/mic.0.2006/004911-0.
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Iron and Pseudomonas aeruginosa biofilm formation.铁与铜绿假单胞菌生物膜形成
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铁螯合剂与外排泵抑制剂对铜绿假单胞菌生长和生物膜形成的协同作用。

Synergistic activities of an efflux pump inhibitor and iron chelators against Pseudomonas aeruginosa growth and biofilm formation.

机构信息

Center for Systems Microbiology, Department of Systems Biology, Technical University of Denmark, 2800 Lyngby, Denmark.

出版信息

Antimicrob Agents Chemother. 2010 Sep;54(9):3960-3. doi: 10.1128/AAC.00463-10. Epub 2010 Jun 21.

DOI:10.1128/AAC.00463-10
PMID:20566773
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC2935009/
Abstract

The efflux pump inhibitor phenyl-arginine-beta-naphthylamide (PAbetaN) was paired with iron chelators 2,2'-dipyridyl, acetohydroxamic acid, and EDTA to assess synergistic activities against Pseudomonas aeruginosa growth and biofilm formation. All of the tested iron chelators synergistically inhibited P. aeruginosa growth and biofilm formation with PAbetaN. PAbetaN-EDTA showed the most promising activity against P. aeruginosa growth and biofilm formation.

摘要

外排泵抑制剂苯丙氨酸-精氨酸-β-萘酰胺（PAbetaN）与铁螯合剂 2,2'-联吡啶、乙酰羟肟酸和 EDTA 配对，以评估它们对铜绿假单胞菌生长和生物膜形成的协同作用。所有测试的铁螯合剂均与 PAbetaN 协同抑制铜绿假单胞菌的生长和生物膜形成。PAbetaN-EDTA 对铜绿假单胞菌的生长和生物膜形成表现出最有前途的活性。