Kawasaki Goro, Yoshitomi Izumi, Yanamoto Souichi, Yamada Shin-Ichi, Kawano Toshihiro, Mizuno Akio
Department of Oral and Maxillofacial Surgery, Unit of Translational Medicine, Course of Medical and Dental Sciences, Nagasaki University Graduate School of Biomedical Sciences.
Gan To Kagaku Ryoho. 2010 Jun;37(6):1035-9.
Thymidylate synthase(TS), dihydropyrimidine dehydrogenase(DPD), and orotate phosphoribosyl transferase(OPRT)are initial key enzymes in the 5-fluorouracil(5-FU)metabolic pathway. In this study, we investigated clinicopathological and immunohistochemical expressions of TS, DPD, and OPRT in oral cancer patients who showed a complete response(CR)to UFT. We also evaluated patients showing a partial response(PR)and stable disease(SD)following UFT. The numbers of CR, PR, and SD cases were 3, 5, and 10, respectively. Pathologically, all CR and PR cases were the well-differentiated type, and 5 out of 10 SD cases were of the moderately or poorly-differentiated type. Three out of the 5 cases of moderately or poorlydifferentiated type were DPD-negative. Most cases of CR and PR were DPD-positive. OPRT expression showed no difference with the UFT response. We suggest that UFT affects high DPD patients with the well-differentiated type, but may not influence low DPD patients with the moderately or poorly-differentiated type.
胸苷酸合成酶（TS）、二氢嘧啶脱氢酶（DPD）和乳清酸磷酸核糖基转移酶（OPRT）是5-氟尿嘧啶（5-FU）代谢途径中的初始关键酶。在本研究中，我们调查了对优福定（UFT）显示完全缓解（CR）的口腔癌患者中TS、DPD和OPRT的临床病理及免疫组化表达情况。我们还评估了接受UFT治疗后显示部分缓解（PR）和疾病稳定（SD）的患者。CR、PR和SD病例数分别为3例、5例和10例。病理上，所有CR和PR病例均为高分化型，10例SD病例中有5例为中分化或低分化型。5例中分化或低分化型病例中有3例DPD阴性。大多数CR和PR病例DPD阳性。OPRT表达与UFT反应无差异。我们认为，UFT对高分化型且DPD水平高的患者有影响，但可能对中分化或低分化型且DPD水平低的患者无影响。
