Ogura Masaharu, Tanaka Nobutaka, Furuya Takatoshi, Nomura Yukihiro, Nagai Motoki, Takahashi Michiro, Takayama Toshio, Hirao Hirofumi, Nakamura Hogara, Suzuki Yoshio
Department of Surgery, Asahi General Hospital.
Gan To Kagaku Ryoho. 2010 Jun;37(6):1125-9.
A 7 0-year-old female underwent distal gastrectomy for gastric cancer in November 2001. She did not wish to receive postoperative adjuvant chemotherapy. In May 2002, her serum carcinoembryonic antigen(CEA)level rose. CT demonstrated liver(S5/6)and lung(S9)metastases in August 2002. We started to treat her with S-1(100mg/day day 1-14 orally), and restaging CT showed complete regression of liver and lung metastases in August 2003. In spite her complete response(CR), we continued S-1 treatment for the successive two years. No adverse reaction to chemotherapy occurred. Although CR was maintained for about 4 years, she was found to have a 9-mm solitary lesion in the upper pole of the spleen in June 2007. After 6 months, this tumor increased to 15mm in size, and we considered it as a solitary metastasis to the spleen from gastric cancer. S-1 chemotherapy was restarted, but tumor size gradually increased. Tumor size finally reached 25mm in December 2008. She underwent splenectomy in January 2009. From then until now, she has not received any chemotherapy, and has been followed well without any recurrence.
一名70岁女性于2001年11月因胃癌接受了远端胃切除术。她不愿接受术后辅助化疗。2002年5月，她的血清癌胚抗原（CEA）水平升高。2002年8月的CT检查显示肝脏（S5/6）和肺部（S9）转移。我们开始用S-1（100mg/天，第1 - 14天口服）对她进行治疗，2003年8月的再分期CT显示肝脏和肺部转移灶完全消退。尽管达到了完全缓解（CR），我们仍连续两年继续使用S-1治疗。未出现化疗不良反应。虽然CR状态维持了约4年，但在2007年6月发现她的脾脏上极有一个9毫米的孤立病灶。6个月后，这个肿瘤增大到15毫米，我们认为它是胃癌转移至脾脏的孤立转移灶。于是重新开始S-1化疗，但肿瘤大小逐渐增大。2008年12月肿瘤大小最终达到25毫米。她于2009年1月接受了脾切除术。从那时起至今，她未接受任何化疗，一直随访良好，无任何复发。
