Department of Joint Disease Research, 22nd Century Medical and Research Center, Graduate School of Medicine, The University of Tokyo, 7-3-1 Hongo, Bunkyo-ku, Tokyo, Japan.
J Bone Miner Metab. 2011 Jan;29(1):96-102. doi: 10.1007/s00774-010-0197-9. Epub 2010 Jun 22.
This prospective cohort study aimed to evaluate the capacity of endogenous sex steroids to predict male osteoporosis (OP) among community-dwelling inhabitants. Among 1,028 male residents aged 40-79 years, 50 men belonging to each age stratum (200 in total) were randomly selected from a resident registration list. In the years 1993, 1996, 2000, and 2003, bone mineral density (BMD) of the lumbar spine and proximal femur was measured by dual-energy X-ray absorptiometry. Serum total estradiol (E(2)) and free testosterone (FT) were measured using samples extracted in 1993. Among the 200 participants at baseline, 153 subjects completed 10-year follow-ups. Mean values of serum E(2) and FT were 22.4 and 9.4 pg/ml, respectively. Rates of change for BMD at the lumbar spine and femoral neck were 0.8% and 0.5% during the first 3 years, 0.0% and 0.5% during 7 years, and 0.8% and -0.3% over 10 years, respectively. According to multivariate regression analysis after adjusting for age and body mass index, mean values of FT were significantly related to the rate of change of BMD at the femoral neck at 3 years (beta = 0.21; r (2) = 0.05; P < 0.01), but not at 7 or 10 years. Serum FT level could offer a useful predictor of bone loss within 3 years.
本前瞻性队列研究旨在评估内源性性激素对社区居民男性骨质疏松症（OP）的预测能力。在 1028 名年龄在 40-79 岁的男性居民中，从居民登记册中随机选择每个年龄组的 50 名男性（共 200 名）。在 1993 年、1996 年、2000 年和 2003 年，通过双能 X 射线吸收法测量腰椎和股骨近端的骨密度（BMD）。使用 1993 年提取的样本测量血清总雌二醇（E(2)）和游离睾酮（FT）。在基线时的 200 名参与者中，有 153 名完成了 10 年随访。血清 E(2)和 FT 的平均值分别为 22.4 和 9.4 pg/ml。腰椎和股骨颈 BMD 的变化率在头 3 年分别为 0.8%和 0.5%，7 年分别为 0.0%和 0.5%，10 年分别为 0.8%和-0.3%。经过年龄和体重指数调整的多变量回归分析显示，FT 的平均值与 3 年时股骨颈 BMD 的变化率显著相关（β=0.21；r (2) = 0.05；P < 0.01），但与 7 年或 10 年时无关。血清 FT 水平可作为 3 年内骨丢失的有用预测指标。
