Wiesik-Szewczyk Ewa, Olesińska Marzena
Instytut Reumatologii, Klinika i Poliklinika Układowych Chorób Tkanki Łacznej.
Pol Merkur Lekarski. 2010 May;28(167):421-3.
This paper presents progress in management of systemic sclerosis, with respect of EULAR recommendation. In the first part we present efficacy of overall immunosupresive treatments and preliminary data of autologous stem cell transplantation based on randomized clinical trials. The second part concerns a treatment specific for target organs: Raynaud's phenomenon, alimentary tract involvement, interstitial lung disease, pulmonary arterial hypertension and scleroderma renal crisis. Despite intensive investigations disease modifying drug therapy is still unknown, but specific organ treatment increase survival and improve health related quality of life.
本文介绍了根据欧洲抗风湿病联盟（EULAR）建议在系统性硬化症管理方面取得的进展。在第一部分，我们基于随机临床试验展示了整体免疫抑制治疗的疗效以及自体干细胞移植的初步数据。第二部分涉及针对靶器官的治疗：雷诺现象、消化道受累、间质性肺病、肺动脉高压和硬皮病肾危象。尽管进行了深入研究，但疾病修饰药物治疗仍然未知，不过针对特定器官的治疗可提高生存率并改善健康相关生活质量。
