Faculty of Chemistry, Adam Mickiewicz University, Poznań, Poland.
Pol J Microbiol. 2010;59(1):49-53.
The synthesis and antimicrobial activity of 31 morpholinium chlorides, divided into five series depending on the substituents attached to the nitrogen atom, N-carboxyalkyl-morpholinium chlorides (1a-e), N-carbalkoxymethyl-N-methyl-morpholinium chlorides (2a-f), N-carbethoxymethyl-N-alkyl-morpholinium chlorides (3a-g), N-carbalkoxymethyl-N-dodecyl-morpholinium chlorides (4a-f) and N-carboxymethyl-N-alkyl-morpholinium chlorides (5a-g) is reported. The compounds investigated were tested for antimicrobial activity against Staphylococcus aureus, Escherichia coli, Proteus vulgaris, Pseudomonas aeruginosa, Candida albicans and Trichophyton menthagrophytes. The most active are compounds with a long N-alkyl group and with the substituent CH2COOC(n)H(2n-1) (n = 8-16).
报告了 31 种吗啉𬭩氯化物的合成和抗菌活性，这些氯化物根据连接在氮原子上的取代基分为五个系列：N-羧基烷基吗啉𬭩氯化物（1a-e）、N-羰甲氧甲基-N-甲基吗啉𬭩氯化物（2a-f）、N-羰乙氧甲基-N-烷基吗啉𬭩氯化物（3a-g）、N-羰甲氧甲基-N-十二烷基吗啉𬭩氯化物（4a-f）和 N-羧甲基-N-烷基吗啉𬭩氯化物（5a-g）。研究了这些化合物对金黄色葡萄球菌、大肠杆菌、普通变形杆菌、铜绿假单胞菌、白色念珠菌和须癣毛癣菌的抗菌活性。活性最强的是具有长的 N-烷基基团和取代基 CH2COOC(n)H(2n-1)（n = 8-16）的化合物。
