Ozawa H, Kurata A, Suzuki S, Fujii K, Kan S
Department of Neurosurgery, Ushioda General Hospital, Kitasato University School of Medicine; Kanagawa, Japan.
Interv Neuroradiol. 2006 Jan 20;12(Suppl 1):148-53. doi: 10.1177/15910199060120S125. Epub 2006 Jun 15.
Polyvinyl alcohol (PVA) particles have been widely used as an embolic material for endovascular treatment of vascular enriched tumors, especially for meningiomas. However, there are disadvantages with their use due to the fact that they are radiolucent, with a very irregular shape and a tendency for self-adhesion. With alternative organic liquids there is also a possibility of toxicity. We have therefore developed a new embolic material, platinum balls, which feature radioopacity, a relatively well-defined oval shape, multi-pitted and indented surfaces on electron microscopy and a lower tendency for self-adhesion Based on positive findings in experimental studies, embolization of meningiomas was conducted with platinum balls in 27 patients and the results compared with findings for a matched group previously treated with PVA particles.Total volume of blood transfused during surgery was comparable in the two cases, although a tendency for lower values was noted with the platinum balls, and outcome was equally positive.
聚乙烯醇(PVA)颗粒已被广泛用作血管丰富性肿瘤血管内治疗的栓塞材料,尤其是用于脑膜瘤。然而,使用它们存在一些缺点,因为它们是射线可透的,形状非常不规则,并且有自粘倾向。使用替代有机液体也存在毒性可能性。因此,我们开发了一种新的栓塞材料——铂球,其具有射线不透性、相对明确的椭圆形、电子显微镜下表面有多孔和凹陷以及较低的自粘倾向。基于实验研究的阳性结果,对27例脑膜瘤患者用铂球进行栓塞,并将结果与先前用PVA颗粒治疗的匹配组的结果进行比较。尽管使用铂球时输血总量有降低的趋势,但两例手术期间的输血总量相当,且结果同样良好。