Hoffmann Thomas, Mølbak Kåre, Paerregaard Anders
Børneafdelingen, Hvidovre Hospital, 2650 Hvidovre, Denmark.
Ugeskr Laeger. 2010 Jun 21;172(25):1910-3.
Infant botulism is a rare disease that affects infants below the age of 12 months following absorption of neurotoxins produced by ingested Clostridium botulinum spores. The clinical manifestations are caused by symmetrical cranial nerve palsies followed by descending, symmetric flaccid paralysis of voluntary muscles. Presenting symptoms include constipation, lethargy, mydriasis and ptosis. The diagnosis is made on the basis of clinical examination and confirmed by isolating the toxin in serum or stools. Treatment consists of supportive intensive care and treatment with antitoxins.
婴儿肉毒中毒是一种罕见疾病，12个月以下婴儿摄入肉毒梭菌孢子产生的神经毒素后会受其影响。临床表现为由对称性颅神经麻痹引起，随后出现随意肌的下行性、对称性弛缓性麻痹。常见症状包括便秘、嗜睡、瞳孔散大和上睑下垂。诊断基于临床检查，并通过在血清或粪便中分离出毒素来确诊。治疗包括支持性重症监护和抗毒素治疗。
