Rubie H, Hartmann O, Giron A, Lemoine G, Gruner M, Brugieres L, Valteau-Couanet D, Robert A, Lemerle J
Pediatric Hematology and Oncology Unit, Hôpital de Purpan, Toulouse, France.
Med Pediatr Oncol. 1991;19(4):253-7. doi: 10.1002/mpo.2950190408.
From 1982 to 1987, 40 children with non-metastatic thoracic neuroblastoma were treated with the same therapeutic regimen. According to TNM staging, there were 11 CS I, 19 CS II, and 10 CS III. All patients underwent surgery; 30 had primary surgical excision; in 10 whose tumors were deemed unresectable, surgery was delayed until after a trial of chemotherapy. Operation was completed by several courses of chemotherapy in case of microscopic residual disease or regional lymph node involvement; radiotherapy was delivered in case of gross residual disease. Using this therapeutic approach, EFS is 92% with a median follow-up of 40 months. Severe complications were rare and sequellae appear to be related to the disease, i.e., neurologic consequences of cord compression.
1982年至1987年，40例非转移性胸段神经母细胞瘤患儿接受了相同的治疗方案。根据TNM分期，有11例为CS I期，19例为CS II期，10例为CS III期。所有患者均接受了手术；30例行初次手术切除；10例肿瘤被认为无法切除，手术推迟至化疗试验后进行。如存在微小残留病灶或区域淋巴结受累，通过几个疗程的化疗完成手术；如存在肉眼可见的残留病灶，则进行放疗。采用这种治疗方法，无事件生存率为92%，中位随访时间为40个月。严重并发症罕见，后遗症似乎与疾病相关，即脊髓压迫的神经学后果。
