Division of Neonatal and Developmental Medicine, Stanford University School of Medicine, 750 Welch Road, Suite 315, Stanford, Palo Alto, CA 94304, USA.
Clin Perinatol. 2010 Jun;37(2):421-38. doi: 10.1016/j.clp.2009.12.001.
Early-onset sepsis remains a major diagnostic problem in neonatal medicine. Definitive diagnosis depends on cultures of blood or other normally sterile body fluids. Abnormal hematological counts, acute-phase reactants, and inflammatory cytokines are neither sensitive nor specific, especially at the onset of illness. Combinations of measurements improve diagnostic test performance, but the optimal selection of analytes has not been determined. The best-established use of these laboratory tests is for retrospective determination that an infant was not infected, based on failure to mount an acute-phase response over the following 24 to 48 hours.
早发性败血症仍然是新生儿医学中的一个主要诊断问题。明确的诊断取决于血液或其他通常无菌体液的培养。异常的血液学计数、急性期反应物和炎症细胞因子既不敏感也不特异，尤其是在疾病开始时。测量值的组合可提高诊断测试性能，但尚未确定最佳分析物选择。这些实验室测试的最佳应用是基于在接下来的 24 至 48 小时内未出现急性期反应，从而回溯性地确定婴儿未感染。
