Lorentz I T, Subramaniam S S, Yiannikas C
Department of Neurology, Westmead Hospital, NSW, Australia.
Mov Disord. 1991;6(2):145-50. doi: 10.1002/mds.870060210.
In a double-blind, placebo-controlled study, 23 patients suffering from intractable spasmodic torticollis (ST) were given successively either botulinum toxin A (BTA) or normal saline by intramuscular injections in the affected muscles. Evaluation was carried out by three blinded observers, using a clinical and video assessment of the severity of torticollis, employing a scoring system described by Tsui (1). Patients were also asked to subjectively comment on changes in the amount of pain and on changes in the activities of daily living (ADL). BTA was proven to be superior on all forms of assessment to placebo, and these results were statistically significant. Side effects mainly consisted of pain at the injection site. Tiredness occurred at equal frequency with BTA and placebo. No serious or systemic side effects were noted. Botulinum toxin is a safe, effective and relatively simple treatment for spasmodic torticollis.
在一项双盲、安慰剂对照研究中，23例患有顽固性痉挛性斜颈（ST）的患者在受影响的肌肉中依次接受肉毒杆菌毒素A（BTA）或生理盐水的肌肉注射。由三名不知情的观察者进行评估，使用对斜颈严重程度的临床和视频评估，并采用Tsui（1）描述的评分系统。患者还被要求主观评价疼痛程度的变化以及日常生活活动（ADL）的变化。在所有形式的评估中，BTA均被证明优于安慰剂，且这些结果具有统计学意义。副作用主要包括注射部位疼痛。BTA和安慰剂导致疲劳的发生率相同。未观察到严重或全身性副作用。肉毒杆菌毒素是一种治疗痉挛性斜颈的安全、有效且相对简单的方法。
