哌克昔林可诱发大鼠全身性脂质沉积症。
Perhexiline induces generalized lipidosis in rats.
作者信息
Lüllmann H, Lüllmann-Rauch R
出版信息
Klin Wochenschr. 1978 Mar 15;56(6):309-10. doi: 10.1007/BF01489178.
PMID:205704
Abstract
Administration of perhexiline (Pexide) to rats causes generalized occurrence of lamellated and crystalloid cytoplasmic inclusions which resemble those described in patients with perhexiline-induced polyneuropathy. It is concluded that perhexiline being an amphiphilic cationic compound is a potent inducer of generalized lipidosis.
摘要
给大鼠施用哌克昔林（沛心达）会导致普遍出现层状和晶体状细胞质内含物，这些内含物与哌克昔林诱发的多发性神经病患者中所描述的相似。得出的结论是，哌克昔林作为一种两亲性阳离子化合物，是全身性脂质沉积症的有力诱导剂。
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