The Graduate School of Nursing, Robert Morris University, Moon Township, Pennsylvania
Diabetes Educ. 2010 Jul-Aug;36(4):657-65. doi: 10.1177/0145721710374369. Epub 2010 Jun 22.
The purpose of this pilot/feasibility study was to evaluate the use of insulin regimens among individuals with poorly controlled type 2 diabetes. In addition, a secondary aim was to build the body of evidence regarding the use of insulin pumps in patients with type 2 diabetes.
The setting was a suburban private endocrinology practice. Patients were a convenience sample of 15 adults, aged 40 to 64 years with poorly controlled type 2 diabetes, as defined by a hemoglobin A1C (A1C) of 8% or higher when continuous subcutaneous insulin infusion (CSII) was initiated. Baseline, 3-month, 6-month, and 1-year A1C, body mass index (BMI), basal and bolus insulin use, and number of office visits were collected through medical record review. Descriptive, independent, and paired t tests were used to evaluate data.
A significant reduction in basal insulin use was found. Significant reductions in A1Cs were found at 3 months, 6 months, and 1 year. A significant increase in BMI was noted.
Results indicated improvement in glycemic control with CSII for some patients with an associated increase in BMI. Reduction of basal insulin use was significant and, for some, cost effective using CSII. Current policies regarding CSII use in patients with type 2 diabetes need to be re-evaluated.
本试点/可行性研究旨在评估胰岛素方案在血糖控制不佳的 2 型糖尿病患者中的应用。此外,次要目的是为 2 型糖尿病患者使用胰岛素泵积累证据。
研究地点为郊区私人内分泌科诊所。患者为 15 名年龄在 40 至 64 岁之间的成年人,根据连续皮下胰岛素输注(CSII)开始时血红蛋白 A1C(A1C)为 8%或更高的标准,他们被诊断为血糖控制不佳的 2 型糖尿病。通过病历回顾收集基线、3 个月、6 个月和 1 年时的 A1C、体重指数(BMI)、基础和餐时胰岛素使用情况以及就诊次数等数据。采用描述性、独立和配对 t 检验对数据进行分析。
发现基础胰岛素用量显著减少。3 个月、6 个月和 1 年时 A1C 显著降低。BMI 显著增加。
结果表明 CSII 可改善某些患者的血糖控制,同时 BMI 也随之增加。CSII 可显著减少基础胰岛素的使用,对某些患者来说具有成本效益。需要重新评估现行关于 2 型糖尿病患者使用 CSII 的政策。