用于止痛的羟考酮复方制剂。
Oxycodone combinations for pain relief.
作者信息
Raffa R B, Pergolizzi J V, Segarnick D J, Tallarida R J
机构信息
Department of Pharmaceutical Sciences, Temple University School of Pharmacy, Philadelphia, Pennsylvania, USA.
出版信息
Drugs Today (Barc). 2010 Jun;46(6):379-98. doi: 10.1358/dot.2010.46.6.1470106.
No single analgesic drug provides the perfect therapeutic/adverse effect profile for every pain condition. In addition to convenience and possibly improved compliance, a combination of analgesic drugs offers the potential, requiring verification, of providing greater pain relief and/or reduced adverse effects than the constituent drugs when used individually. We review here analgesic combinations containing oxycodone. We found surprisingly little preclinical information about the analgesic or adverse effect profiles of the combinations (with acetaminophen, paracetamol, nonsteroidal anti-inflammatory drugs, morphine, gabapentin or pregabalin). Clinical experience and studies suggest that the combinations are safe and effective and may offer certain advantages. As with all combinations, the profile of adverse effects must also be determined in order to provide the clinician with the overall benefit/risk assessment.
没有一种单一的镇痛药能为每种疼痛状况提供完美的治疗/不良反应特征。除了方便性以及可能提高的依从性外，镇痛药联合使用具有这样一种潜力（尚需验证），即与单独使用各成分药物相比，能提供更强的疼痛缓解和/或减少不良反应。我们在此综述含羟考酮的镇痛联合用药。我们惊讶地发现，关于这些联合用药（与对乙酰氨基酚、扑热息痛、非甾体抗炎药、吗啡、加巴喷丁或普瑞巴林联用）的镇痛或不良反应特征，临床前信息极少。临床经验和研究表明，这些联合用药安全有效，且可能具有某些优势。与所有联合用药一样，还必须确定不良反应特征，以便为临床医生提供全面的获益/风险评估。
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