Fédération de Bactériologie-Hygiène-Virologie, Centre Hospitalo-Universitaire Timone, Marseille, France.
J Med Virol. 2010 Aug;82(8):1431-7. doi: 10.1002/jmv.21835.
Self-sampling using vaginal swabs could be a valuable alternative to screen for cervical cancer for women who do not attend regular cytological screening. The aim of this study was to determine the prevalence of high and low-risk HPV types and of HPV type 16 and 18 DNA load in self-collected vaginal swabs from 35- to 69-year-old Southern French women of low socioeconomic level or migrant populations who do not attend regular cervical screening. A good concordance (93.1%) was found between cervical brush and vaginal swabs in 29 samples. Self-collected vaginal swabs were examined from 120 women. HPV infection was found in 28 women (23.3%; median age 48 years), 17 (14.1%) of whom harbored high-risk HPV types. HPV type 16 was the high risk type found most frequently, followed by types 53, 31, 18, 58, and 66. The low-risk type detected most frequently was HPV type 6, followed by types 61, 70, and 81. The mean HPV 16 and 18 load was 6.3 log(10) copies/10(6) cells and 2.4 log(10) copies/10(6) cells, respectively. These results suggest that vaginal self-swabs can be a reliable tool for cervical cancer screening in non-attending and inadequately screened elderly women.
自我采样使用阴道拭子可能是一种有价值的替代方法，可以对不参加常规细胞学筛查的女性进行宫颈癌筛查。本研究的目的是确定 35 至 69 岁的法国南部低社会经济水平或移民人群中未参加常规宫颈筛查的女性中，高危和低危 HPV 类型以及 HPV 16 和 18 型 DNA 负荷的流行率。在 29 份样本中，宫颈刷和阴道拭子之间发现了良好的一致性（93.1%）。对 120 名女性进行了自我采集的阴道拭子检查。28 名女性（23.3%；中位年龄 48 岁）发现 HPV 感染，其中 17 名（14.1%）携带高危 HPV 类型。最常发现的高危 HPV 类型是 HPV 16 型，其次是 HPV 53、31、18、58 和 66 型。最常检测到的低危 HPV 类型是 HPV 6 型，其次是 HPV 61、70 和 81 型。HPV 16 和 18 的平均负荷分别为 6.3 log(10)拷贝/10(6)个细胞和 2.4 log(10)拷贝/10(6)个细胞。这些结果表明，阴道自我拭子可能是不参加和筛查不足的老年女性宫颈癌筛查的可靠工具。
