Department of Dermatology, Päijät-Häme Central Hospital, Lahti, Finland.
Photochem Photobiol. 2010 Sep-Oct;86(5):1174-8. doi: 10.1111/j.1751-1097.2010.00769.x.
The objective of the study was to compare Bacillus subtilis spore film dosimeters with a Robertson Berger UV meter (RB meter) and diary records for assessing personal UV-B doses during a 13-day heliotherapy (HT) for atopic dermatitis (AD). In addition, the relationship between the personal UV-B dose and change in serum 25-hydroxyvitamin D (25(OH)D) was studied. Altogether 21 adult patients with AD completed the study arranged in the Canary Islands, either in January or March 2005. The spore film dosimeters were used throughout the day during the HT. Serum 25(OH)D was analyzed using radioimmunoassay. The mean personal UV-B dose measured with the dosimeters was 75 SED in January and 131 SED in March. The respective results gained from the RB meter combined with diary records were 63 SED and 119 SED showing a close correlation with the dosimeter results. Serum 25(OH)D concentration increased by 9.7nmol L(-1) in January and by 26.0 7nmol L(-1) in March. The increase in serum 25(OH)D correlated with the UV-B dose received. The patients complied well to use the dosimeters. We conclude spore films to be a feasible and reliable personal UV dosimeter in vivo in field conditions.
本研究旨在比较枯草芽孢杆菌孢子膜剂量计与 Robertson Berger 紫外线计 (RB 计) 和日记记录,以评估在特应性皮炎 (AD) 13 天光疗 (HT)期间个人接受的 UV-B 剂量。此外,还研究了个人 UV-B 剂量与血清 25-羟维生素 D(25(OH)D)变化之间的关系。共有 21 名成年 AD 患者于 2005 年 1 月或 3 月在加那利群岛完成了这项研究。在 HT 期间,孢子膜剂量计全天使用。血清 25(OH)D 采用放射免疫分析法分析。剂量计测量的平均个人 UV-B 剂量在 1 月为 75 SED,在 3 月为 131 SED。结合日记记录得出的 RB 计结果分别为 63 SED 和 119 SED,与剂量计结果密切相关。血清 25(OH)D 浓度在 1 月增加了 9.7nmol L(-1),在 3 月增加了 26.0 7nmol L(-1)。血清 25(OH)D 的增加与接受的 UV-B 剂量相关。患者很好地配合使用了剂量计。我们得出结论,孢子膜是现场条件下可行且可靠的体内个人 UV 剂量计。