甲醛与季铵盐-15 接触过敏的关系。斑贴试验反应强度的影响。

Relationship between formaldehyde and quaternium-15 contact allergy. Influence of strength of patch test reactions.

机构信息

Department of Dermatology, University Medical Centre Groningen, University of Groningen, PO Box 30.001, 9700 RB Groningen, The Netherlands.

出版信息

Contact Dermatitis. 2010 Oct;63(4):187-91. doi: 10.1111/j.1600-0536.2010.01712.x.

DOI:10.1111/j.1600-0536.2010.01712.x

PMID:20573164

Abstract

BACKGROUND

In groups of patients with formaldehyde allergy, many have positive patch tests to quaternium-15. Conversely, of patients allergic to quaternium-15, over half also react to formaldehyde.

OBJECTIVES

To test our hypothesis that patients with stronger patch test reactions to formaldehyde are more likely to react to quaternium-15, attesting to the aetiological role for formaldehyde in such co-reactivity.

METHODS

Retrospective analysis of all patients patch tested with formaldehyde and quaternium-15 in the European baseline series between 1994 and 2009 (TRUE test).

RESULTS

In a group of 86 patients allergic to formaldehyde, 73% co-reacted to quaternium-15; in the subgroup of 70 women, the percentage was 83. In both groups, more reactions were observed to quaternium-15 in the patients with a ++ reaction compared to the patients with a + reaction to formaldehyde. Conversely, stronger reactions to quaternium-15 were significantly more often associated with formaldehyde sensitivity in a group of 107 patients reacting to quaternium-15 and a subgroup of 88 women. In men, such effects were not observed and only 5 of 16 (31%) men allergic to formaldehyde also reacted to quaternium-15.

CONCLUSIONS

In women, but not in men, stronger reactions to formaldehyde lead to more positive quaternium-15 patch tests.

摘要

背景

在 Formaldehyde 过敏的患者群体中，许多人对 Quaternium-15 的斑贴试验呈阳性。相反，对 Quaternium-15 过敏的患者中，超过一半也对 Formaldehyde 有反应。

目的

检验我们的假设，即对 Formaldehyde 斑贴试验反应较强的患者更有可能对 Quaternium-15 产生反应，这证明了 Formaldehyde 在这种共同反应中的病因作用。

方法

对 1994 年至 2009 年期间在欧洲基本系列中接受 Formaldehyde 和 Quaternium-15 斑贴试验的所有患者进行回顾性分析（TRUE 试验）。

结果

在 86 名对 Formaldehyde 过敏的患者中，有 73%的患者出现了共同反应；在 70 名女性患者的亚组中，这一比例为 83%。在这两个组中，与对 Formaldehyde 呈 + 反应的患者相比，对 ++ 反应的患者对 Quaternium-15 的反应更多。相反，在对 Quaternium-15 有反应的 107 名患者和对 88 名女性的亚组中，对 Quaternium-15 有更强反应的患者更常与 Formaldehyde 敏感性相关。在男性中，没有观察到这种影响，只有 16 名对 Formaldehyde 过敏的男性中的 5 名（31%）也对 Quaternium-15 有反应。