Serviço de Dermatologia, Hospitais da Universidade de Coimbra, Praceta Mota Pinto, 3000-075 Coimbra, Portugal.
Contact Dermatitis. 2010 Aug;63(2):85-8. doi: 10.1111/j.1600-0536.2010.01707.x. Epub 2010 Jun 18.
Benzydamine, a non-steroidal anti-inflammatory drug (NSAID) in use for more than four decades, has been reported to cause photosensitivity.
To study the results of photopatch testing to benzydamine and the clinical features of the dermatitis during a 3-year period (2006-2008).
During this period, 74 patients with photodermatoses were photopatch tested with an extended baseline series of allergens including benzydamine and in suspicious cases, with drugs that contain it. Test sites were irradiated on D2 with 5 J/cm(2) and readings were performed on D2 and D4.
Ten patients (six females/four males), aged 21-84 years (mean 64.9) had a positive photopatch test to benzydamine [1-5% petrolatum (pet.) from Bial-Aristegui] and to drugs that contain it (Tantum verde oral solution and Momen gel). Nine patients had lower lip cheilitis and one lichenified eczema on photo-exposed sites.
Photosensitivity from both topical and systemic benzydamine has been occasionally described, mainly in southern Spain. Despite its widespread use and its known photosensitizing capacity, photoallergic contact dermatitis from benzydamine is probably underdiagnosed as the clinical presentation of mainly the lip and chin is not typical of photoallergic contact dermatitis and benzydamine is not part of most photoallergen series.
苯扎氯铵是一种使用超过四十年的非甾体抗炎药（NSAID），已被报道会引起光敏感性。
研究苯扎氯铵光斑贴试验的结果以及在三年期间（2006-2008 年）皮炎的临床特征。
在此期间，74 例光皮病患者接受了包括苯扎氯铵在内的过敏原扩展基础系列的光斑贴试验，在可疑病例中，还与含有它的药物进行了光斑贴试验。测试部位在 D2 用 5 J/cm²照射，并在 D2 和 D4 进行读数。
10 名患者（6 名女性/4 名男性），年龄 21-84 岁（平均 64.9 岁）对苯扎氯铵[1-5%的凡士林（pet.）来自 Bial-Aristegui]和含有它的药物（Tantum verde 口服液和 Momen 凝胶）呈光斑贴试验阳性。9 名患者下唇唇炎，1 名患者在光暴露部位出现苔藓样湿疹。
局部和全身使用苯扎氯铵引起的光敏感性偶尔有报道，主要在西班牙南部。尽管苯扎氯铵广泛使用且已知具有光致敏性，但由于主要表现为嘴唇和下巴的临床表现并非光过敏性接触性皮炎的典型表现，而且苯扎氯铵也不是大多数光过敏原系列的一部分，因此光过敏性接触性皮炎可能被漏诊。
