结直肠癌化疗后肝转移的评估：超顺磁性氧化铁 MRI 与 FDG-PET/CT。
Assessment of liver metastases from colorectal adenocarcinoma following chemotherapy: SPIO-MRI versus FDG-PET/CT.
机构信息
Department of Radiology, E.O. Ospedali Galliera, Mura delle Cappuccine 14, 16128 Genova, Italy.
出版信息
Radiol Med. 2010 Oct;115(7):1087-100. doi: 10.1007/s11547-010-0560-x. Epub 2010 Jun 23.
PURPOSE
This study compared superparamagnetic iron-oxide-enhanced magnetic resonance imaging (SPIO-MRI) and combined fluorodeoxyglucose positron emission tomography and computed tomography (FDG-PET/CT) in evaluating liver metastases from colorectal adenocarcinoma following chemotherapy.
MATERIALS AND METHODS
Nineteen patients were included in this retrospective study. SPIO-MRI and PET/CT results were compared with surgery, intraoperative ultrasound and pathology results in 11 patients and with the follow-up in eight patients.
RESULTS
SPIO-MRI and PET/CT identified 125 and 71 metastases, respectively. False negative lesions were 11 for SPIO-MRI and 65 for PET/CT. In the whole study population, the per-lesion analysis of SPIO-MRI and PET/CT showed a sensitivity of 92% and 52% (p<0.001) and the per-segment analysis a sensitivity of 99% and 79% (p<0.001), respectively. In patients who underwent surgery, the per-lesion analysis of SPIO-MRI and PET/CT showed a sensitivity of 85% and 58% (p<0.05) and the per-segment analysis a sensitivity of 97% and 63% (p<0.05), respectively. In patients who underwent follow-up, the per-lesion analysis of SPIO-MRI and PET/CT showed a sensitivity of 97% and 47% (p<0.001) and the per-segment analysis a sensitivity of 100% and 63% (p<0.007), respectively. For lesions ≥15 and <30 mm and for lesions <15 mm, SPIO-MRI demonstrated a higher sensitivity than PET/CT (p<0.001).
CONCLUSIONS
SPIO-MRI appears superior to PET/CT in evaluating liver metastases from colorectal adenocarcinoma following chemotherapy.
目的
本研究比较超顺磁性氧化铁增强磁共振成像（SPIO-MRI）和氟代脱氧葡萄糖正电子发射断层扫描和计算机断层扫描（FDG-PET/CT）在评估结直肠癌化疗后肝转移中的作用。
材料与方法
本回顾性研究纳入 19 例患者。SPIO-MRI 和 PET/CT 结果与 11 例患者的手术、术中超声和病理结果及 8 例患者的随访结果进行比较。
结果
SPIO-MRI 和 PET/CT 分别发现 125 个和 71 个转移灶。SPIO-MRI 漏诊 11 个病灶，而 PET/CT 漏诊 65 个病灶。在整个研究人群中，SPIO-MRI 和 PET/CT 的病灶分析显示敏感性分别为 92%和 52%（p<0.001），节段分析显示敏感性分别为 99%和 79%（p<0.001）。在接受手术的患者中，SPIO-MRI 和 PET/CT 的病灶分析显示敏感性分别为 85%和 58%（p<0.05），节段分析显示敏感性分别为 97%和 63%（p<0.05）。在接受随访的患者中，SPIO-MRI 和 PET/CT 的病灶分析显示敏感性分别为 97%和 47%（p<0.001），节段分析显示敏感性分别为 100%和 63%（p<0.007）。对于直径≥15mm 且<30mm 和直径<15mm 的病灶，SPIO-MRI 的敏感性高于 PET/CT（p<0.001）。
结论
SPIO-MRI 在评估结直肠癌化疗后肝转移方面优于 PET/CT。
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