Robust generation of lead compounds for protein-protein interactions by computational and MCR chemistry: p53/Hdm2 antagonists.
作者信息
Czarna Anna, Beck Barbara, Srivastava Stuti, Popowicz Grzegorz M, Wolf Siglinde, Huang Yijun, Bista Michal, Holak Tad A, Dömling Alexander
机构信息
Max-Planck-Institut für Biochemie, Martinsried, Germany.
出版信息
Angew Chem Int Ed Engl. 2010 Jul 19;49(31):5352-6. doi: 10.1002/anie.201001343.
Abstract
摘要
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Robust generation of lead compounds for protein-protein interactions by computational and MCR chemistry: p53/Hdm2 antagonists.通过计算化学和多组分反应化学稳健生成用于蛋白质-蛋白质相互作用的先导化合物：p53/Hdm2拮抗剂
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本文引用的文献
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The rise of fragment-based drug discovery.片段化合物药物发现的兴起。
Nat Chem. 2009 Jun;1(3):187-92. doi: 10.1038/nchem.217.
2
ANCHOR: a web server and database for analysis of protein-protein interaction binding pockets for drug discovery.ANCHOR：一个用于药物发现的蛋白质-蛋白质相互作用结合口袋分析的网络服务器和数据库。
Nucleic Acids Res. 2010 Jul;38(Web Server issue):W407-11. doi: 10.1093/nar/gkq502. Epub 2010 Jun 4.
3
Structures of low molecular weight inhibitors bound to MDMX and MDM2 reveal new approaches for p53-MDMX/MDM2 antagonist drug discovery.小分子抑制剂与 MDMX 和 MDM2 结合的结构揭示了用于 p53-MDMX/MDM2 拮抗剂药物发现的新方法。
Cell Cycle. 2010 Mar 15;9(6):1104-11. doi: 10.4161/cc.9.6.10956.
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The Gewald multicomponent reaction.格瓦尔德多组分反应。
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5
New substructure filters for removal of pan assay interference compounds (PAINS) from screening libraries and for their exclusion in bioassays.新型亚结构筛选器，可用于从筛选库中去除泛分析干扰化合物（PAINS），并在生物测定中对其进行排除。
J Med Chem. 2010 Apr 8;53(7):2719-40. doi: 10.1021/jm901137j.
6
Identification and characterization of the first small molecule inhibitor of MDMX.鉴定和表征第一个 MDMX 的小分子抑制剂。
J Biol Chem. 2010 Apr 2;285(14):10786-96. doi: 10.1074/jbc.M109.056747. Epub 2010 Jan 15.
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Knowledge-based virtual screening: application to the MDM4/p53 protein-protein interaction.基于知识的虚拟筛选：应用于MDM4/p53蛋白质-蛋白质相互作用
Methods Mol Biol. 2009;575:173-94. doi: 10.1007/978-1-60761-274-2_7.
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Robust NMR screening for lead compounds using tryptophan-containing proteins.使用含色氨酸的蛋白质对先导化合物进行稳健的核磁共振筛选。
J Am Chem Soc. 2009 Jun 10;131(22):7500-1. doi: 10.1021/ja901863h.
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High affinity interaction of the p53 peptide-analogue with human Mdm2 and Mdmx.p53肽类似物与人Mdm2和Mdmx的高亲和力相互作用。
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