Feng Binbin, Zhang Jianhai, Zhang Jifen, Chen Gang, Xu Xiaoyu
Southwest University, Chongqing 400716, China.
Zhongguo Zhong Yao Za Zhi. 2010 Apr;35(7):900-3.
To study the pharmacokinetics of tetramethylpyrazine (TMP), ferulic acid and their compatibility.
Twenty-four Sprague-Dawley rats were randomly divided into 3 groups: TMP 20 mg x kg(-1), ferulic acid 20 mg x kg(-1) and TMP 20 mg x kg(-1) + ferulic acid 20 mg x kg(-1). All the rats were given intragastric administration then blood samples were obtained from fossa orbitalis at several time points. All the plasmas concentrations were analyzed by HPLC method and the data were treated by DAS 2.0 program.
The main pharmacokinetics parameters of TMP 20 mg x kg(-1) group, ferulic acid 20 mg x kg(-1) and TMP 20 mg x kg(-1) + ferulic acid 20 mg x kg(-1) were as follows: t(max) 0.5 h, t1/2 0.856 h,MRT 1.321 h, AUC 5.112 microg x h(-1) x L(-1), C(max) 2.834 microg x L(-1); t(max) 0.083 h, t1/2 1.024 h, MRT 1.324 h, AUC 1.581 microg x h(-1) x L(-1), C(max) 1.492 microg x L(-1); t(max) 0.583 h, t1/2 37.901 h, MRT 3.798 h, AUC 4.097 microg x h(-1) x L(-1), C(max)1.571 microg x L(-1); t(max) 0.6 h, t1/2 7.860 h, MRT 2.894 h, AUC 1.984 microg x h(-1) x L(-1), C(max) 1.03 microg x L(-1), respectively.
The experiments suggested that the compatibility of TMP and ferulic acid had interaction in pharmacokinetics; all the t1/2 and MRT were prolonged and had the effect of lente liberates.
研究川芎嗪（TMP）、阿魏酸及其配伍的药代动力学。
将24只Sprague-Dawley大鼠随机分为3组：川芎嗪20mg·kg⁻¹组、阿魏酸20mg·kg⁻¹组和川芎嗪20mg·kg⁻¹+阿魏酸20mg·kg⁻¹组。所有大鼠均经灌胃给药，然后在多个时间点从眶窝采集血样。所有血浆浓度采用高效液相色谱法分析，数据用DAS 2.0程序处理。
川芎嗪20mg·kg⁻¹组、阿魏酸20mg·kg⁻¹组和川芎嗪20mg·kg⁻¹+阿魏酸20mg·kg⁻¹组的主要药代动力学参数如下：t(max) 0.5小时，t1/2 0.856小时，MRT 1.321小时，AUC 5.112μg·h⁻¹·L⁻¹，C(max) 2.834μg·L⁻¹；t(max) 0.083小时，t1/2 1.024小时，MRT 1.324小时，AUC 1.581μg·h⁻¹·L⁻¹，C(max) 1.492μg·L⁻¹；t(max) 0.583小时，t1/2 37.901小时，MRT 3.798小时，AUC 4.097μg·h⁻¹·L⁻¹，C(max)1.571μg·L⁻¹；t(max) 0.6小时，t1/2 7.860小时，MRT 2.894小时，AUC 1.984μg·h⁻¹·L⁻¹，C(max) 1.03μg·L⁻¹，分别。
实验表明，川芎嗪与阿魏酸的配伍在药代动力学上有相互作用；所有t1/2和MRT均延长，具有缓释作用。
