[乙肝病毒核心蛋白作为一种表位疫苗载体：综述]
[Hepatitis B virus core protein as an epitope vaccine carrier: a review].
作者信息
Yin Ying, Xu Junjie, Chen Wei
机构信息
State Key Laboratory of Pathogen and Biosecurity, Institute of Microbiology and Epidemiology, Beijing 100071, China.
出版信息
Sheng Wu Gong Cheng Xue Bao. 2010 Apr;26(4):431-8.
PMID:20575429
Abstract
Hepatitis B virus core (HBc) proteins have been used as carrier for foreign epitopes since the 1980s. They could self-assemble into icosahedral particles. Foreign epitopes could be inserted into HBc protein in various protein regions, including the N- or C-terminal and the major immunodominant region (MIR). The factors relevant in the design of HBc particles for vaccine purpose are summarized in this review.
摘要
自20世纪80年代以来，乙肝病毒核心（HBc）蛋白就被用作外源表位的载体。它们能够自组装成二十面体颗粒。外源表位可插入HBc蛋白的各个蛋白区域，包括N端或C端以及主要免疫显性区域（MIR）。本文综述了用于疫苗目的的HBc颗粒设计中的相关因素。
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