Yin Ying, Xu Junjie, Chen Wei
State Key Laboratory of Pathogen and Biosecurity, Institute of Microbiology and Epidemiology, Beijing 100071, China.
Sheng Wu Gong Cheng Xue Bao. 2010 Apr;26(4):431-8.
Hepatitis B virus core (HBc) proteins have been used as carrier for foreign epitopes since the 1980s. They could self-assemble into icosahedral particles. Foreign epitopes could be inserted into HBc protein in various protein regions, including the N- or C-terminal and the major immunodominant region (MIR). The factors relevant in the design of HBc particles for vaccine purpose are summarized in this review.
自20世纪80年代以来，乙肝病毒核心（HBc）蛋白就被用作外源表位的载体。它们能够自组装成二十面体颗粒。外源表位可插入HBc蛋白的各个蛋白区域，包括N端或C端以及主要免疫显性区域（MIR）。本文综述了用于疫苗目的的HBc颗粒设计中的相关因素。
