S-烯丙半胱氨酸的抗糖尿病作用：对实验性糖尿病患者血浆和组织糖蛋白的影响。
Antidiabetic effect of S-allylcysteine: Effect on plasma and tissue glycoproteins in experimental diabetes.
机构信息
Research and Development Centre, Bharathiyar University, Coimbatore 641046, Tamil Nadu, India.
出版信息
Phytomedicine. 2010 Dec 1;17(14):1086-9. doi: 10.1016/j.phymed.2010.04.008. Epub 2010 Jun 23.
The present study was conducted to investigate the effect of S-allylcysteine (SAC) on dearrangement in glycoprotein levels in the streptozotocin induced diabetic model. SAC (150 mg/kg b.w./day) was administered orally for 45 days to normal and diabetic rats. STZ-induced diabetic rats showed significant increase in blood glucose and glycoprotein components such as hexose, hexosamine, fucose and sialic acid in plasma, liver and kidneys of diabetic rats. Oral administration of SAC to diabetic rats for a period of 45 days normalized all the above-mentioned biochemical parameters. The antihyperglycemic effect of SAC was compared with glyclazide, a well-known antihyperglycemic drug. The present study indicates that SAC possesses a significantly beneficial effect on the glycoprotein moiety in addition to its antidiabetic effect.
本研究旨在探讨 S-烯丙半胱氨酸（SAC）对链脲佐菌素诱导的糖尿病模型中糖蛋白水平紊乱的影响。SAC（150mg/kg b.w./天）以口服方式给予正常和糖尿病大鼠，共 45 天。STZ 诱导的糖尿病大鼠的血糖和糖蛋白成分（如血浆、肝脏和肾脏中的己糖、己糖胺、岩藻糖和唾液酸）显著增加。SAC 对糖尿病大鼠的口服给药 45 天可使上述所有生化参数正常化。SAC 的降血糖作用与已知的降血糖药物格列齐特进行了比较。本研究表明，SAC 除了具有抗糖尿病作用外，对糖蛋白部分还具有显著的有益作用。
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