Departamento de Bioquímica, Instituto de Química, Universidade de São Paulo, São Paulo, Brazil.
Mech Ageing Dev. 2010 Jul-Aug;131(7-8):503-10. doi: 10.1016/j.mad.2010.04.009. Epub 2010 May 31.
Helicases are essential enzymes that utilize the energy of nucleotide hydrolysis to drive unwinding of nucleic acid duplexes. Helicases play roles in all aspects of DNA metabolism including DNA repair, DNA replication and transcription. The subcellular locations and functions of several helicases have been studied in detail; however, the roles of specific helicases in mitochondrial biology remain poorly characterized. This review presents important recent advances in identifying and characterizing mitochondrial helicases, some of which also operate in the nucleus.
解旋酶是一种必需的酶，它利用核苷酸水解的能量来驱动核酸双链的解开。解旋酶在包括 DNA 修复、DNA 复制和转录在内的所有 DNA 代谢过程中都发挥着作用。几种解旋酶的亚细胞定位和功能已经得到了详细研究；然而，特定解旋酶在线粒体生物学中的作用仍未得到充分描述。这篇综述介绍了鉴定和描述线粒体解旋酶的重要最新进展，其中一些解旋酶也在核内发挥作用。
