University Women's Hospital, 3010 Bern, Switzerland.
Arch Gynecol Obstet. 2010 Nov;282(5):577-80. doi: 10.1007/s00404-010-1532-z. Epub 2010 Jun 25.
Iron-deficiency anaemia during pregnancy and postpartum occurs frequently and may lead to severe maternal and foetal complications. New treatment regimens include intravenous iron administration in particular clinical situations. The aim of the study was to determine optimal diagnostic and therapeutic approaches to iron-deficiency anaemia during pregnancy and postpartum.
The evidence from data available from published studies and recommendations regarding diagnosis and treatment were reviewed. As conclusions, recommendations are given by an expert panel.
During pregnancy, oral iron therapy is given as first-line treatment. In cases with lack of efficacy, unwarranted side effects or very low haemoglobin values, intravenous iron treatment with iron carboxymaltose is a preferable alternative, although data regarding safety are limited. In the postpartum period, haemoglobin values less than 95 g/L are treated ideally by intravenous carboxymaltose, leading to more rapid haemoglobin recovery.
New intravenous iron preparations such as iron carboxymaltose have an excellent efficacy, side effect profile and advantages as compared to oral iron preparations for particular clinical indications.
妊娠期和产后缺铁性贫血较为常见，可能导致严重的母婴并发症。新的治疗方案包括在特定临床情况下静脉补铁。本研究旨在确定妊娠期和产后缺铁性贫血的最佳诊断和治疗方法。
对已发表研究数据中的证据和诊断与治疗建议进行了回顾。专家组给出了结论和推荐。
妊娠期首选口服铁剂治疗。若疗效不佳、出现不应有的副作用或血红蛋白值非常低，则可使用静脉铁剂（如葡萄糖酸亚铁）治疗，但相关安全性数据有限。产后血红蛋白值＜95 g/L 时，理想的治疗方法是使用静脉注射羧甲麦芽糖铁，可更快地恢复血红蛋白水平。
与口服铁剂相比，新的静脉用铁剂（如葡萄糖酸亚铁）在特定临床情况下具有更好的疗效、安全性和优势。
