Jensen J J, Møller M L, Lund J O, Trap-Jensen J
Frederiksberg Hospital, klinisk fysiologisk/nuklearmedicinsk afdeling.
Ugeskr Laeger. 1991 Jun 3;153(23):1648-51.
The value of renography before and after angiotensin converting enzyme inhibition with captopril (captopril renography) as a test for renovascular hypertension was studied in fourteen hypertensive patients. The captopril renography was performed with 99mTc-DTPA by means of a gammacamera, allowing determination of single kidney glomerular filtration rate (SKGFR). In all patients determination of renal vein plasma renin concentration and renal angiography were carried out. Eleven patients showed an elevated unilateral renin secretion. All of these had a significant decrease of SKGFR in one or both kidneys after captopril. Three patients without a lateralized renal renin secretion showed no change in SKGFR. In five patients with presumed essential hypertension there was no change in SKGFR during captopril renography. Captopril renography with 99mTc-DTPA gammacamera renography is a promising tool for identification of unilateral increased renin secretion in hypertensive patients suspected of renovascular hypertension.
在14例高血压患者中，研究了用卡托普利抑制血管紧张素转换酶前后的肾图（卡托普利肾图）作为肾血管性高血压检测方法的价值。采用γ相机通过99mTc - DTPA进行卡托普利肾图检查，以测定单肾肾小球滤过率（SKGFR）。对所有患者均进行了肾静脉血浆肾素浓度测定和肾血管造影。11例患者显示单侧肾素分泌升高。所有这些患者在服用卡托普利后，一侧或双侧肾脏的SKGFR均显著降低。3例无肾素分泌侧化的患者SKGFR无变化。5例疑似原发性高血压患者在卡托普利肾图检查期间SKGFR无变化。用99mTc - DTPAγ相机肾图进行卡托普利肾图检查，是识别疑似肾血管性高血压的高血压患者单侧肾素分泌增加的一种有前景的工具。
