Sahenk Z, Mendell J R, Couri D, Nachtman J
Neurology. 1978 May;28(5):485-7. doi: 10.1212/wnl.28.5.485.
A generalized toxic polyneuropathy was identified in a 23-year-old woman after excessive intentional inhalation of compressed N2O delivery from cartridges through a whipped-cream dispenser. The chronology of the patient's N2O abuse correlated clearly with two episodes of recurrent polyneuropathy. The toxic effects were limited to the nervous system, primarily involving the peripheral nerves, although some signs suggested a possible effect on the cerebellum or its connections. The findings on sural nerve biopsy were nonspecific, characterized principally by axonal degeneration. Gas chromatographic analysis of the N2O cartridges dispensed through the whipped-cream canister revealed an exposure to N2O and 26 other compounds. Three of these, trichloroethylene, toluene, and phenol, are known neurotoxins.
一名23岁女性在故意过量吸入通过奶油发泡器从气瓶中释放的压缩一氧化二氮后，被诊断出患有全身性中毒性多发性神经病。患者滥用一氧化二氮的时间线与两次复发性多发性神经病发作明显相关。毒性作用仅限于神经系统，主要累及周围神经，尽管一些体征表明可能对小脑或其连接部位有影响。腓肠神经活检结果无特异性，主要特征为轴突变性。对通过奶油发泡器喷出的一氧化二氮气瓶进行气相色谱分析，发现其中含有一氧化二氮和其他26种化合物。其中三种，即三氯乙烯、甲苯和苯酚，是已知的神经毒素。
