从珍贵游动放线菌中得到一种新的抗肿瘤ansamitocin。

A new antitumour ansamitocin from Actinosynnema pretiosum.

机构信息

State Key Laboratory of Phytochemistry and Plant Resources in West China, Kunming Institute of Botany, Chinese Academy of Sciences, Kunming 650204, P.R. China.

出版信息

Nat Prod Res. 2010 Jul;24(12):1146-50. doi: 10.1080/14786410902916552.

DOI:10.1080/14786410902916552

PMID:20582809

Abstract

A new compound of ansamitocin was isolated from the extracts of fermentation medium of mutant strain HGF052 derived from Actinosynnema pretiosum ssp. aurantium ATCC 31565, and identified as N-demethyl-desepoxy-9-methoxy-maytansinol (1) on the basis of extensive spectroscopic methods. Bioassay results showed that compound 1 had cytotoxic activity against HL-60 and BEL-7402 cell lines.

摘要

从桔黄小单孢菌（Actinosynnema pretiosum ssp. aurantium ATCC 31565）突变株 HGF052 发酵培养基的提取物中分离得到一种新的安丝菌素类化合物，并通过广泛的光谱方法鉴定为 N-去甲基-去环氧-9-甲氧基-美坦新醇（1）。生物测定结果表明，化合物 1 对 HL-60 和 BEL-7402 细胞系具有细胞毒性活性。