Division of Immunology, Haematology, Oncology, Bone Marrow Transplantation and Autoimmune Diseases, Department of Paediatrics, Leiden University Medical Centre, Leiden, The Netherlands.
Pediatr Blood Cancer. 2010 Aug;55(2):344-8. doi: 10.1002/pbc.22500.
Chemokine receptor/ligand interactions orchestrate the migration of cells to peripheral tissues such as the skin. We analysed chemokine receptor expression by acute myeloid leukaemic (AML) cells present in peripheral blood (n = 7), bone marrow (n = 6), or skin (n = 11) obtained from 15 paediatric AML patients with skin involvement and in 10 AML patients without skin involvement. High percentages of circulating CCR2(pos) AML cells were only detected in patients with extramedullary disease. Skin-residing AML cells displayed a different set of receptors in situ, namely: CCR5, CXCR4, CXCR7 and CX3CR1. These results suggest the involvement of different chemokine/chemokine receptor interactions in homing and retention of AML blasts in the skin.
趋化因子受体/配体相互作用协调细胞向皮肤等外周组织的迁移。我们分析了 15 例皮肤受累的儿科急性髓系白血病（AML）患者和 10 例无皮肤受累的 AML 患者外周血（n=7）、骨髓（n=6）或皮肤（n=11）中存在的 AML 细胞的趋化因子受体表达。只有在外髓疾病患者中才检测到循环 CCR2（pos）AML 细胞的高百分比。皮肤驻留的 AML 细胞原位显示出不同的受体集，即：CCR5、CXCR4、CXCR7 和 CX3CR1。这些结果表明，不同的趋化因子/趋化因子受体相互作用参与了 AML 原始细胞在皮肤中的归巢和滞留。
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