Department of Otolaryngology-Head and Neck Surgery, Columbia University College of Physicians and Surgeons, New York, New York, USA.
Laryngoscope. 2010 Jul;120(7):1342-4. doi: 10.1002/lary.20948.
OBJECTIVES/HYPOTHESIS: To review a new technique during total thyroidectomy that facilitates parathyroid gland preservation and selective autotransplantation utilizing topical 2% plain lidocaine as a spasmolytic/vasodilator agent.
Retrospective case series review at a university hospital.
The study population comprised 100 consecutive patients (84 women and 16 men; mean age, 52 years) undergoing total thyroidectomy from January 2007 to December 2008. Interventions were: parathyroid glands (PGs) with signs of devascularization treated with a topical solution of 2% plain lidocaine in an attempt to restore blood flow before committing to autotransplantation.
The main outcome measure was the incidence of hypoparathyroidism. A total of 40 parathyroid glands were autotransplanted. None of the 100 patients developed permanent hypoparathyroidism. There were no adverse effects utilizing this technique.
In our experience, the use of lidocaine spasmolysis is a useful technique in thyroid surgery for salvaging devascularized PGs. Its utility as a selection method for PG autotransplantation incurs minimal risk or cost and might further reduce the incidence of permanent hypoparathyroidism. Further study is warranted.
目的/假设:回顾一种新的技术,即在全甲状腺切除术过程中利用 2%普通利多卡因作为痉挛/血管扩张剂来促进甲状旁腺的保存和选择性自体移植。
在一所大学医院进行的回顾性病例系列研究。
研究人群包括 100 例连续患者(84 名女性和 16 名男性;平均年龄 52 岁),他们于 2007 年 1 月至 2008 年 12 月期间接受了全甲状腺切除术。干预措施为:对有血运不良迹象的甲状旁腺(PGs)用 2%普通利多卡因的局部溶液进行处理,试图在进行自体移植之前恢复血流。
主要观察指标是甲状旁腺功能减退症的发生率。共有 40 个甲状旁腺被自体移植。这 100 例患者中没有一例发生永久性甲状旁腺功能减退症。该技术无不良反应。
根据我们的经验,利多卡因痉挛缓解术在甲状腺手术中是一种有用的技术,可用于挽救血运不良的 PGs。作为 PG 自体移植的选择方法,其使用具有最小的风险或成本,可能进一步降低永久性甲状旁腺功能减退症的发生率。需要进一步研究。