铱催化 N-芳基氨甲酰氯与内炔的环化反应。
Iridium-catalyzed annulation of N-arylcarbamoyl chlorides with internal alkynes.
机构信息
Department of Energy and Hydrocarbon Chemistry, Graduate School of Engineering, Kyoto University, Nishikyo-ku, Kyoto 615-8510, Japan.
出版信息
J Am Chem Soc. 2010 Jul 21;132(28):9602-3. doi: 10.1021/ja104153k.
PMID:20583793
Abstract
An iridium complex successfully catalyzed the annulation of various N-arylcarbamoyl chlorides with internal alkynes to afford 2-quinolones in good to excellent yields. The present reaction is widely applicable to substrates with various functionalities. An amide-iridacycle complex was isolated, and it is likely that such an iridacycle species is a key intermediate in the catalytic reaction.
摘要
铱配合物成功地催化了各种 N-芳基碳酰氯与内部炔烃的环化反应，以良好到优秀的收率得到了 2-喹诺酮。本反应广泛适用于具有各种官能团的底物。分离出了酰胺-铱环配合物，这种铱环物种可能是催化反应中的关键中间体。
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