[脑血流量、脑血容量、氧利用率和氧摄取分数：年龄的影响]

[Cerebral blood flow, cerebral blood volume, oxygen utilization and oxygen extraction fraction: the influence of age].

作者信息

Zhang Yu, Peng Ying-yin, Chen Guo-yue, Chen Wu-fan

机构信息

School of Biomedical Engineering, Southern Medical University, Guangzhou 510515, China.

出版信息

Nan Fang Yi Ke Da Xue Xue Bao. 2010 Jun;30(6):1237-9.

PMID:20584645

Abstract

OBJECTIVE

To analyze the changes of cerebral blood flow (CBF), cerebral blood volume (CBV), oxygen utilization (CMRO2) and oxygen extraction fraction (OEF) with age.

METHODS

The PET images of 7 young (21.0-/+1 years old) and 7 aged volunteers (60.9-/+4.7 years old) were analyzed to identify the areas where CBF, CBV, CMRO2, OEF had significant differences with age. The images were anatomically normalized by statistical parametric mapping (SPM2). A voxel by voxel calculation was performed to obtain the slope with age. Voxels which had statistically significant differences (P<0.05) with age were shown both on global and ROIs brain images.

RESULTS

The CBF decreased with age as was consistent with previous reports. The age-related changes in CBV and CMRO2 were similar to CBF, but OEF increased with age.

CONCLUSION

CBF, CBV and CMRO2 generally decline with age. The increase in OEF with age suggests a greater reduction in CBF than in CMRO2. The most significant decreases of CBF and CMRO2 occur in the convexity of the frontal cortex and inferior parietal cortex in all the functional images, while in the white matter, the influence of age is minimal.

摘要

目的

分析脑血流量（CBF）、脑血容量（CBV）、氧利用率（CMRO2）和氧摄取分数（OEF）随年龄的变化。

方法

分析7名年轻志愿者（21.0±1岁）和7名老年志愿者（60.9±4.7岁）的PET图像，以确定CBF、CBV、CMRO2、OEF与年龄有显著差异的区域。图像通过统计参数映射（SPM2）进行解剖学标准化。逐体素计算以获得随年龄变化的斜率。在全脑和感兴趣区（ROI）脑图像上显示与年龄有统计学显著差异（P<0.05）的体素。