通过磷酸化对WASp的调控：激活作用还是其他功能？
Regulation of WASp by phosphorylation: Activation or other functions?
作者信息
Dovas Athanassios, Cox Dianne
出版信息
Commun Integr Biol. 2010 Mar;3(2):101-5. doi: 10.4161/cib.3.2.10759.
Abstract
Wiskott-Aldrich Syndrome protein (WASp) is an actin nucleation-promoting factor that regulates actin polymerisation via the Arp2/3 complex. Its mutation in human syndromes has led to extensive studies on the regulation and activities of this molecule. Several mechanisms for the regulation of WASp activity have been proposed, however, the role of tyrosine phosphorylation remains controversial, particularly due to inconsistencies between results obtained through biochemical and cell biological approaches. In this mini-review, we are addressing the major aspects of WASp regulation with an emphasis on the role of tyrosine phosphorylation on WASp activities.
摘要
威斯科特-奥尔德里奇综合征蛋白（WASp）是一种肌动蛋白成核促进因子，通过Arp2/3复合物调节肌动蛋白聚合。其在人类综合征中的突变引发了对该分子调控和活性的广泛研究。目前已提出多种调节WASp活性的机制，然而，酪氨酸磷酸化的作用仍存在争议，特别是由于生化方法和细胞生物学方法所获结果之间存在不一致。在本综述中，我们将探讨WASp调节的主要方面，重点关注酪氨酸磷酸化对WASp活性的作用。
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