Family Medicine Research Centre, School of Health and Medical Sciences, Orebro University, Orebro, Sweden.
Food Nutr Res. 2010 Jun 16;54:5141. doi: 10.3402/fnr.v54i0.5141.
Lactase non-persistent (LNP) individuals may be lactose intolerant and therefore on a more restricted diet concerning milk and milk products compared to lactase persistent (LP) individuals. This may have an impact on body fat mass.
This study examines if LP and LNP children and adolescents, defined by genotyping for the LCT-13910 C > T polymorphism, differ from each other with regard to milk and milk product intake, and measures of body fat mass.
Children (n=298, mean age 9.6 years) and adolescents (n=386, mean age 15.6 years), belonging to the Swedish part of the European Youth Heart Study, were genotyped for the LCT-13910 C > T polymorphism. Dietary intakes of reduced and full-fat dairy varieties were determined.
LNP (CC genotype) subjects consumed less milk, soured milk and yoghurt compared to LP (CT/TT genotype) subjects (p<0.001). Subsequent partitioning for age group attenuated this observation (p=0.002 for children and p=0.023 in adolescents). Six subjects were reported by parents to be 'lactose intolerant', none of whom were LNP. LNP children and adolescents consumed significantly less reduced fat milk and milk products than LP children and adolescents (p=0.009 for children and p=0.001 for adolescents).
We conclude that LP is linked to an overall higher milk and dairy intake, but is not linked to higher body fat mass in children and adolescents.
乳糖不耐受（LNP）个体可能无法持续产生乳糖酶，因此与乳糖持续型（LP）个体相比，他们的饮食可能会受到限制，不能摄入过多的牛奶和奶制品。这可能会对体脂肪量产生影响。
本研究通过基因分型检测 LCT-13910 C > T 多态性，来检验 LP 和 LNP 儿童和青少年在牛奶和奶制品的摄入量以及体脂肪量方面是否存在差异。
来自欧洲青年心脏研究瑞典部分的 298 名儿童（平均年龄 9.6 岁）和 386 名青少年（平均年龄 15.6 岁）接受了 LCT-13910 C > T 多态性的基因分型检测。评估了减少和全脂乳制品的摄入量。
LNP（CC 基因型）受试者的牛奶、酸奶和酸奶摄入量明显低于 LP（CT/TT 基因型）受试者（p<0.001）。进一步按年龄分组后，这种观察结果减弱（p=0.002 儿童组和 p=0.023 青少年组）。有 6 名儿童被父母报告为“乳糖不耐受”，但他们均非 LNP 个体。LNP 儿童和青少年的低脂牛奶和奶制品摄入量明显低于 LP 儿童和青少年（p=0.009 儿童组和 p=0.001 青少年组）。
LP 与整体更高的牛奶和乳制品摄入量有关，但与儿童和青少年的体脂肪量增加无关。
