Nakamura K, Nakamura K
Naunyn Schmiedebergs Arch Pharmacol. 1977 Sep;299(2):143-8. doi: 10.1007/BF00498555.
In young, spontaneously hypertensive rats (SHR), a preganglionic, nerve-dependent, elevation of choline acetyltransferase (ChAc) and tyrosine hydroxylase (TH) activities was found in celiac ganglia as compared with those in young, normotensive Kyoto Wistar rats, that was not present in superior cervical ganglia, stellate ganglia and adrenal glands. The rise in both enzyme activities in the celiac ganglion disappeared in adult SHR. An elevation of plasma norepinephrine and dopamine beta-hydroxylase levels found in prehypertensive SHR, a probable indication of peripheral sympathetic activation, disappeared after the bilateral removal of the celiac ganglion. However, ganglionectomy did not change the subsequent development of hypertension. These results indicate that the faster maturation of the celiac ganglion and the end organs it innervates in yount SHR are causally related to the activation of the peripheral sympathetic nervous system. The peripheral sympathetic activation in young SHR is regarded as a warning sign but this does not trigger the development of hypertension.
与年轻的正常血压京都Wistar大鼠相比，在年轻的自发性高血压大鼠（SHR）中，发现腹腔神经节中胆碱乙酰转移酶（ChAc）和酪氨酸羟化酶（TH）的活性有节前、神经依赖性升高，而在颈上神经节、星状神经节和肾上腺中则不存在这种情况。成年SHR腹腔神经节中这两种酶活性的升高消失。在高血压前期SHR中发现血浆去甲肾上腺素和多巴胺β-羟化酶水平升高，这可能是外周交感神经激活的一个指标，在双侧切除腹腔神经节后消失。然而，神经节切除并没有改变高血压随后的发展。这些结果表明，年轻SHR腹腔神经节及其所支配的终末器官的更快成熟与外周交感神经系统的激活存在因果关系。年轻SHR中的外周交感神经激活被视为一个警示信号，但这并不会引发高血压的发展。
