Wong V K, Quagliata R, Adler R, Kim K S
Department of Pediatrics, Childrens Hospital of Los Angeles, CA 90027.
Am J Dis Child. 1991 Jul;145(7):742-5.
We studied the immunologic responsiveness to Haemophilus influenzae type b capsular polysaccharide-Neisseria meningitidis group b outer membrane protein conjugate vaccine (PRP-NOMP) in children 2 to 42 months of age with vaccine dosages containing 7.5, 15, or 30 micrograms of PRP. Overall, PRP-NOMP was highly immunogenic. Geometric mean titers of anti-PRP antibody increased from 0.09 to 3.3 mg/L and 6.6 mg/L following each dose of vaccine, respectively, in the 2- to 18-month age group. Similarly, anti-PRP antibody geometric mean titers increased from 0.12 to 5.9 mg/L in the older than 18-month age group. However, we noted an apparent inverse relationship between vaccine dosages and immune responses following two doses of PRP-NOMP in 2- to 18-month-old children. Anti-PRP antibody geometric mean titers were 12.0, 6.9, and 3.5 mg/L, respectively, after the second dose of vaccine containing 7.5, 15, or 30 micrograms of PRP. Additional studies are needed to understand the mechanisms responsible for this inverse relationship and also to determine the optimal dosage of PRP-NOMP for young children.
我们研究了2至42月龄儿童对b型流感嗜血杆菌结合疫苗（PRP-NOMP）的免疫反应，疫苗剂量分别含7.5、15或30微克PRP。总体而言，PRP-NOMP具有高度免疫原性。在2至18月龄年龄组中，每次接种疫苗后，抗PRP抗体的几何平均滴度分别从0.09毫克/升增至3.3毫克/升和6.6毫克/升。同样，在18月龄以上年龄组中，抗PRP抗体几何平均滴度从0.12毫克/升增至5.9毫克/升。然而，我们注意到在2至18月龄儿童中，两剂PRP-NOMP接种后，疫苗剂量与免疫反应之间存在明显的负相关关系。含7.5、15或30微克PRP的疫苗第二剂接种后，抗PRP抗体几何平均滴度分别为12.0、6.9和3.5毫克/升。需要进一步研究以了解造成这种负相关关系的机制，并确定幼儿PRP-NOMP的最佳剂量。
