Bershteĭna L M
Probl Endokrinol (Mosk). 1978 Mar-Apr;24(2):111-5.
In studying the thyroid hormone binding with the water-salt extracts of the adenohypophysis and the hypothalamus of male rats after Schreiber it was shown that with ageing there occurred in the adenohypophysis a redistribution of T4 and T3 binding in the direction fo an increase of the T4/T3 coefficient, and a reduction of the relative T3 binding, the latter bordering with the significant one. Some reduction of the T4/T3 coefficient, both in comparison with the rest of the tissues under study and in age aspect, was peculiar to the posterior hypothalamus. In the rats-tumour-carriers some changes in the thyroid hormone binding (reduction of the T4/T3 index in the posterior hypothalamus and its sufficiently high values in the adenohypophysis and the anterior hypothalamus) were similar to those observed in normal and ageing rats.
在研究施赖伯之后雄性大鼠腺垂体和下丘脑的水盐提取物与甲状腺激素的结合时发现，随着年龄增长，腺垂体中T4和T3结合发生重新分布，T4/T3系数增大，相对T3结合减少，后者接近显著水平。与所研究的其他组织相比以及从年龄方面来看，下丘脑后部的T4/T3系数均有一定程度降低。在荷瘤大鼠中，甲状腺激素结合的一些变化（下丘脑后部T4/T3指数降低，腺垂体和下丘脑前部该指数值足够高）与正常和老龄大鼠中观察到的变化相似。
