Bal Yusuf, Adas Mine, Helvaci Aysen
Second Internal Medicine Clinic, Okmeydani Training and Research Hospital, Istanbul, Turkey.
Bratisl Lek Listy. 2010;111(4):200-4.
To investigate the relationship between insulin resistance and tumor necrosis (TNF)-alpha, interleukin (IL)-6, C-reactive protein (CRP) in obese women.
Obesity and type 2 diabetes are associated with insulin resistance, the mechanisms of which remain poorly understood.
Forty obese (35.8 +/- 9.6 years) and 20 non-obese women (31.1 +/- 7.7) were recruited between June 2002 and February 2003 at the Okmeydaný Training and Research Hospital, Istanbul, Turkey. The obese group was equally divided into two according ?to their WHR (> 0.8 and 0.8). Subjects with blood pressure values higher than 140/90 mmHg, pathological findings on standard 12-lead EC3 and leukocytosis and glucose levels > 100 mg/dl were excluded.
Plasma insulin (p < 0.0001) and fasting glucose levels (p<0.0001), and HOMA values (p < 0.0001) in the obese group were higher than in the controls. Serum triglyceride and VLDL levels were higher in the obese group (p < 0.0001 in both), whereas HDL cholesterol levels were higher in the lean control group (p < 0.0001). However, no difference was observed between two groups in terms of total cholesterol and LDL-cholesterol levels. The serum levels of both TNF-alpha, IL-6 and CRP were found elevated in the obese group (p < 0.05, p < 0.05, p < 0.01, respectively). In the subgroup analysis, only the HOMA values and TNF-alpha levels were found higher in the android obese group (p < 0.05 and p < 0.0001, respectively).
Insulin resistance seems to be one of the major causes of obesity-related complications due to increased secretion of TNF-alpha, IL-6 and CRP together with android obesity (Tab. 5, Ref. 33).
研究肥胖女性中胰岛素抵抗与肿瘤坏死因子（TNF）-α、白细胞介素（IL）-6、C反应蛋白（CRP）之间的关系。
肥胖和2型糖尿病与胰岛素抵抗相关，但其机制仍知之甚少。
2002年6月至2003年2月期间，在土耳其伊斯坦布尔的奥克梅丹培训与研究医院招募了40名肥胖女性（35.8±9.6岁）和20名非肥胖女性（31.1±7.7岁）。肥胖组根据腰臀比（>0.8和≤0.8）平均分为两组。排除血压值高于140/90 mmHg、标准12导联心电图有病理发现、白细胞增多且血糖水平>100 mg/dl的受试者。
肥胖组的血浆胰岛素（p<0.0001）、空腹血糖水平（p<0.0001）和稳态模型评估（HOMA）值（p<0.0001）均高于对照组。肥胖组的血清甘油三酯和极低密度脂蛋白（VLDL）水平较高（两者均p<0.0001），而瘦对照组的高密度脂蛋白胆固醇水平较高（p<0.0001）。然而，两组在总胆固醇和低密度脂蛋白胆固醇水平方面未观察到差异。肥胖组的血清TNF-α、IL-6和CRP水平均升高（分别为p<0.05、p<0.05、p<0.01）。在亚组分析中，仅发现男性型肥胖组的HOMA值和TNF-α水平较高（分别为p<0.05和p<0.0001）。
胰岛素抵抗似乎是肥胖相关并发症的主要原因之一，这是由于TNF-α、IL-6和CRP的分泌增加以及男性型肥胖所致（表5，参考文献33）。
