Anadolu University, Faculty of Pharmacy, Department of Pharmaceutical Chemistry, Yunus Emre campus Tepebasi, 26470 Eskişehir, Turkey.
Eur J Med Chem. 2010 Sep;45(9):4383-7. doi: 10.1016/j.ejmech.2010.06.011. Epub 2010 Jun 12.
Some triazolo-pyrazoline derivatives were synthesized to investigate their potential antidepressant activities. The chemical structures of the compounds were elucidated by IR, NMR and FAB(+)-MS spectral data and elemental analyses. Antidepressant-like activities of the test compounds (100 mg/kg) were screened using both modified forced swimming and tail suspension tests. Rota-Rod test was performed for the examination of probable neurological deficits due to the test compounds, which may interfere with the test results. The test compounds in the series exhibited different levels of antidepressant activities when compared to reference drug fluoxetine. None of the test compounds changed motor coordination of animals when assessed in the Rota-Rod test. Therefore, experimental results in this study were not interfered with motor abnormalities.
一些三唑并吡唑啉衍生物被合成出来以研究它们的潜在抗抑郁活性。化合物的化学结构通过红外光谱、核磁共振和快原子轰击（FAB(+)-MS）谱数据及元素分析来阐明。采用改良强迫游泳和悬尾试验对测试化合物（100mg/kg）的抗抑郁样活性进行筛选。进行转棒试验以检查由于测试化合物引起的可能的神经缺陷，这可能会干扰测试结果。与参考药物氟西汀相比，该系列中的测试化合物表现出不同水平的抗抑郁活性。在转棒试验中评估时，没有一种测试化合物改变动物的运动协调能力。因此，本研究中的实验结果不受运动异常的干扰。
