Katafuchi T, Hattori Y, Nagatomo I, Koizumi K, Silverstein E
Department of Physiology, State University of New York, Brooklyn 11203.
Am J Physiol. 1991 Jun;260(6 Pt 2):R1152-8. doi: 10.1152/ajpregu.1991.260.6.R1152.
The involvement of angiotensin II (ANG II) in the genetic polydipsia of the STR/N strain of mice was investigated. Daily water intake of the polydipsic inbred STR/N of both sexes ranged between five and eight times that of nonpolydipsic controls: STR/1N, a mutant of the STR/N, and Swiss-Webster (S/W) mice. Nevertheless the diurnal pattern of drinking was maintained in the STR/N. There was no difference in daily food intake, arterial blood pressure, and plasma renin activity among the three groups. Drinking responses to 48 h of water deprivation were not significantly different between the polydipsic mice and their control groups. Captopril, an angiotensin I converting-enzyme inhibitor, injected subcutaneously just before the dark period, reduced drinking for 6 h in the polydipsic strain only. Food intake of all three groups of mice was not affected. Similarly the ANG II antagonist saralasin, [Sar1,-Ile8]ANG II, injected into the lateral cerebroventricle just before the dark period, significantly reduced water intake for 6 h after injection in the polydipsic mice only. Intracerebroventricular injection of ANG II increased drinking in the nondeprived controls but not in the polydipsic mice. These findings suggest that the polydipsia in the STR/N mice may involve, at least in part, the ANG II system in the brain.
研究了血管紧张素II（ANG II）在STR/N品系小鼠遗传性烦渴中的作用。两性的遗传性烦渴近交系STR/N的每日饮水量是不烦渴对照组（STR/1N，STR/N的一个突变体，以及瑞士-韦伯斯特（S/W）小鼠）的五到八倍。然而，STR/N小鼠仍保持昼夜饮水模式。三组之间的每日食物摄入量、动脉血压和血浆肾素活性没有差异。烦渴小鼠与其对照组在48小时禁水后的饮水反应没有显著差异。在黑暗期前皮下注射血管紧张素I转换酶抑制剂卡托普利，仅使烦渴品系的饮水减少6小时。三组小鼠的食物摄入量均未受影响。同样，在黑暗期前向侧脑室注射ANG II拮抗剂沙拉新（[Sar1，-Ile8]ANG II），仅使烦渴小鼠注射后6小时的饮水量显著减少。向脑室注射ANG II可增加未禁水对照组的饮水量，但对烦渴小鼠无效。这些发现表明，STR/N小鼠的烦渴可能至少部分涉及大脑中的ANG II系统。
