Department of Neurosurgery, Seoul National University College of Medicine, 101 Daehangno, Jongno-gu, Seoul, Korea.
J Neurol Neurosurg Psychiatry. 2011 Feb;82(2):224-7. doi: 10.1136/jnnp.2009.178806. Epub 2010 Jun 28.
The radiological characteristics of World Health Organization grade III oligodendroglial tumours in relation to chromosome 1p and 19q deletions were analysed.
56 patients recently diagnosed with anaplastic oligodendroglioma (AO, n=49) or anaplastic oligoastrocytoma (AOA, n=7) were studied. Their preoperative magnetic resonance images were examined. Deletions of chromosome 1p and 19q were determined using the fluorescence in situ hybridisation method. Both 1p and 19q chromosomes had deletions (1p19q codeletion) in 39 patients (36 AO and 3 AOA).
Tumors associated with the 1p19q codeletion were predominantly located in the frontal lobe (p=0.044). The magnetic resonance image characteristics of indistinct tumour borders (p=0.005 on T1, p=0.036 on T2) and a heterogeneous intratumoural signal intensity (p=0.033 on T1, p=0.041 on T2) were significantly correlated with the 1p19q codeletion. Analysis of patient survival showed those with the 1p19q-co-deleted tumours survived significantly longer than those lacking the 1p19q codeletion (p=0.042). The presence of a heterogeneous signal intensity in T2-weighted images, a characteristic significantly related to the 1p19q codeletion, indicated a favourable prognosis for patients' survival (HR; 0.125, 95% CI, 0.016 to 0.963, p=0.046) based on multivariate analysis.
A relationship between radiological characteristics and molecular signatures in AO/AOAs was shown. It is believed that radiological characteristics have prognostic value as a surrogate marker for molecular characteristics.
分析与染色体 1p 和 19q 缺失相关的世界卫生组织 3 级少突胶质细胞瘤的影像学特征。
研究了 56 例最近被诊断为间变性少突胶质细胞瘤（AO，n=49）或间变性少突星形细胞瘤（AOA，n=7）的患者。检查了他们术前的磁共振图像。使用荧光原位杂交法确定染色体 1p 和 19q 的缺失。39 例患者（36 例 AO 和 3 例 AOA）存在 1p 和 19q 染色体缺失（1p19q 联合缺失）。
与 1p19q 联合缺失相关的肿瘤主要位于额叶（p=0.044）。肿瘤边界模糊（T1 时 p=0.005，T2 时 p=0.036）和肿瘤内信号强度不均匀（T1 时 p=0.033，T2 时 p=0.041）的磁共振图像特征与 1p19q 联合缺失显著相关。对患者生存情况进行分析发现，存在 1p19q 联合缺失的患者的生存期明显长于缺乏 1p19q 联合缺失的患者（p=0.042）。T2 加权图像中不均匀信号强度的存在，这一特征与 1p19q 联合缺失显著相关，提示患者生存预后良好（HR：0.125，95%CI：0.016 至 0.963，p=0.046），这是基于多变量分析的结果。
显示了 AO/AOAs 中的影像学特征与分子特征之间的关系。人们认为影像学特征作为分子特征的替代标志物具有预后价值。
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