From the Division of Neuroradiology, Department of Radiology.
Department of Computational Medicine and Bioinformatics, Michigan Medicine.
Cancer J. 2021;27(5):344-352. doi: 10.1097/PPO.0000000000000545.
Advanced imaging techniques provide a powerful tool to assess the intratumoral and intertumoral heterogeneity of gliomas. Advances in the molecular understanding of glioma subgroups may allow improved diagnostic assessment combining imaging and molecular tumor features, with enhanced prognostic utility and implications for patient treatment. In this article, a comprehensive overview of the physiologic basis for conventional and advanced imaging techniques is presented, and clinical applications before and after treatment are discussed. An introduction to the principles of radiomics and the advanced integration of imaging, clinical outcomes, and genomic data highlights the future potential for this field of research to better stratify and select patients for standard as well as investigational therapies.
高级成像技术为评估胶质瘤的瘤内和瘤间异质性提供了有力的工具。对胶质瘤亚群分子认识的进步可能允许通过将成像和分子肿瘤特征相结合来进行改进的诊断评估，从而提高预后能力并影响患者的治疗。本文全面介绍了常规和高级成像技术的生理基础，并讨论了治疗前后的临床应用。对放射组学原理以及成像、临床结果和基因组数据的高级整合的介绍突出了该研究领域的未来潜力，可以更好地对患者进行分层并选择标准治疗和研究性治疗。
