Pulmonary Hypertension Center, University of Colorado-Denver, 12401 E. 17th Ave., Box L957, Aurora, CO 80045, USA.
Psychosomatics. 2010 Jul-Aug;51(4):339-339.e8. doi: 10.1176/appi.psy.51.4.339.
In patients with left-heart disease, depressive symptoms have a significant impact on functional status and quality of life. The prevalence of depressive symptoms, and their impact on patients with pulmonary arterial hypertension (PAH) is understudied.
The authors investigated the prevalence of depressive symptoms in PAH and their correlation with physical functioning.
Consecutive outpatients with PAH (idiopathic; or associated with scleroderma, congenital heart disease, or anorexiant use) seen in two university PAH clinics were screened. At two outpatient visits, 8 to 16 weeks apart, patients completed the PHQ-8, a well-validated instrument for grading severity of depressive symptoms; they were assessed for cardiac functional class (FC), and performed a 6-minute walk-distance test (6MWD).
A group of 100 patients (88% women, 50% with idiopathic PAH) were enrolled. At baseline, 15% of subjects had symptoms suggestive of major depressive disorder; 40% had mild-to-moderate depressive symptoms; and 45% had no-to-minimal depressive symptoms.
Depression is common in patients with PAH, with 55% demonstrating depressive symptoms. These results suggest that screening patients with PAH will identify a large proportion of patients who might benefit from depression therapy.
在左心疾病患者中，抑郁症状对功能状态和生活质量有重大影响。抑郁症状的患病率及其对肺动脉高压（PAH）患者的影响研究不足。
作者研究了 PAH 患者中抑郁症状的患病率及其与身体机能的相关性。
连续筛查了在两家大学 PAH 诊所就诊的 PAH 门诊患者（特发性；或与硬皮病、先天性心脏病或食欲抑制剂使用相关）。在相隔 8 至 16 周的两次门诊就诊时，患者完成了 PHQ-8，这是一种用于评估抑郁症状严重程度的经过充分验证的工具；他们评估了心功能分级（FC），并进行了 6 分钟步行距离测试（6MWD）。
共纳入了 100 名患者（88%为女性，50%为特发性 PAH）。基线时，15%的患者有明显的重性抑郁障碍症状；40%有轻度至中度抑郁症状；45%无至轻度抑郁症状。
PAH 患者中抑郁很常见，55%的患者有抑郁症状。这些结果表明，对 PAH 患者进行筛查将确定很大一部分可能受益于抗抑郁治疗的患者。
