Perimenopausal postpartum depression after conception by assisted reproductive technology.

BACKGROUND

Women conceiving after the onset of the menopausal transition may experience hormonal fluctuations that predispose them to postpartum depression. Conception by assisted reproductive technology (ART) may increase this risk.

OBJECTIVE

This case report highlights the hormonal and pathophysiological changes that may contribute to the development of postpartum depression during perimenopause.

METHOD

The authors report on the case of a perimenopausal woman who developed postpartum depression after conception by ART.

RESULTS

The patient responded well to antidepressant treatment, estrogen replacement, and psychotherapy.

CONCLUSION

Research into perimenopausal postpartum depression in the setting of ART may lead to improved screening and treatment for at-risk patients.