Kawarai Shinpei, Ishihara Jun, Masuda Kenichi, Yasuda Nobutaka, Ohmori Keitaro, Sakaguchi Masahiro, Asami Yasuhiro, Tsujimoto Hajime
First Department of Veterinary Microbiology, School of Veterinary Medicine, Azabu University, Kanagawa, Japan.
J Vet Med Sci. 2010 Nov;72(11):1413-21. doi: 10.1292/jvms.10-0014. Epub 2010 Jun 25.
There has been a need for improvement of the elimination diet used for diagnosis of adverse food reaction (AFR) in dogs. Recently, a novel elimination diet composed of a mixture of amino acids and potatoes was developed. We evaluated the efficacy of the elimination diet for diagnosis of AFR in dogs. Twenty dogs that were suspected to have allergic dermatitis were enrolled in a 2-month food elimination trial using the diet. Before and after the trial, the clinical symptoms were evaluated based on the change in canine atopic dermatitis extent and severity index (CADESI), pruritus score and medication score. Of the 20 dogs, 15 completed the food elimination trial. The remaining 5 dogs were removed from the trial because of diet unpalatability, skin disease progression or diarrhea. On the basis of evaluation of the clinical scores, we observed that the clinical symptoms improved in 11 of the 15 dogs that completed the food elimination trial. Provocative challenge was performed in 10 of the 11 dogs that showed improvement in their clinical symptoms. Of the 10 dogs, 7 were diagnosed as having AFR against food ingredients such as pork, beef, chicken and wheat because their skin symptoms reappeared after intake of these ingredients. The results of the food elimination trial and the provocative challenge indicated the usefulness of the novel elimination diet for diagnosis of AFR.
一直以来都需要改进用于诊断犬类食物不良反应（AFR）的排除饮食。最近，一种由氨基酸和土豆混合物组成的新型排除饮食被开发出来。我们评估了这种排除饮食在诊断犬类AFR方面的功效。二十只疑似患有过敏性皮炎的犬只参加了一项为期两个月的使用该饮食的食物排除试验。在试验前后，根据犬类特应性皮炎范围和严重程度指数（CADESI）、瘙痒评分和用药评分的变化来评估临床症状。在这二十只犬中，十五只完成了食物排除试验。其余五只犬因饮食不可口、皮肤病进展或腹泻而退出试验。基于临床评分的评估，我们观察到在完成食物排除试验的十五只犬中，有十一只的临床症状有所改善。对临床症状有所改善的十一只犬中的十只进行了激发性挑战。在这十只犬中，七只被诊断为对猪肉、牛肉、鸡肉和小麦等食物成分患有AFR，因为它们在摄入这些成分后皮肤症状再次出现。食物排除试验和激发性挑战的结果表明这种新型排除饮食在诊断AFR方面是有用的。
