Havemann U, Kuschinsky K
Pharmacology. 1978;16(5):295-9. doi: 10.1159/000136782.
In slices of rat striata, incubated in a depolarizing medium (53 mM K+), morphine decreased by concentration of cAMP even in concentrations as low as 0.5 micron. This effect was inhibited by naloxone. Levorphanol, but not dextrorphan, induced a similar effect as morphine. In tissue, homogenized in a hypotonic medium, morphine (5-50 micron) also slightly decreased the concentration of cAMP, which was antagonized by naloxone. Neigher slices nor homogenates of morphine-withdrawn rats showed any alteration in the concentration of cAMP.
在置于去极化培养基（53 mM钾离子）中孵育的大鼠纹状体切片中，吗啡即使在低至0.5微米的浓度下也会使环磷酸腺苷（cAMP）浓度降低。这种作用被纳洛酮抑制。左啡诺而非右啡烷产生了与吗啡相似的作用。在低渗培养基中匀浆的组织中，吗啡（5 - 50微米）也会轻微降低cAMP浓度，这一作用被纳洛酮拮抗。吗啡戒断大鼠的切片和匀浆中cAMP浓度均未显示出任何变化。
