Chemistry Section, Laboratory of Comparative Carcinogenesis, National Cancer Institute at Frederick, Frederick, MD 21702, USA.
Chem Commun (Camb). 2010 Aug 21;46(31):5799-801. doi: 10.1039/c0cc00849d. Epub 2010 Jun 30.
In contrast to amidines bearing ionizable alpha-CH bonds, which react with nitric oxide (NO) to add diazeniumdiolate groups at their alpha-carbons, benzamidine forms an N-bound diazeniumdiolate that can be further derivatized at the other amidine nitrogen and/or the terminal oxygen to form caged NO compounds as potential NO prodrugs.
与带有可离子化的 α-CH 键的脒基不同，它们与一氧化氮 (NO) 反应，在其 α-碳原子上添加重氮烷氧基团，苯甲脒形成 N-键合的重氮烷氧基团，可进一步在另一个脒氮原子和/或末端氧原子上衍生化，形成笼状 NO 化合物作为潜在的 NO 前药。
