Department of Medical Oncology, Shanghai Changzheng Hospital, affiliated to The Second Military Medical University, Shanghai, People's Republic of China.
J Surg Oncol. 2010 Sep 15;102(4):325-30. doi: 10.1002/jso.21644.
To investigate the clinicopathological role of expression of vascular endothelial growth factor (VEGF) and cortactin, as well as whether their expression are independent predictors of tumor recurrence following curative resection of gastric cancer.
One hundred twenty-eight patients with gastric cancer were included in this study. Formalin-fixed paraffin-embedded specimens were stained for VEGF and cortactin, and the correlation between the staining, clinicopathological parameters and prognostic power were analyzed.
Of the 128 patients studied, 58 (45.3%) and 71 (55.5%) cases were strongly positive for VEGF and cortactin, respectively. VEGF expression correlated with Lauren classification (P < 0.001), pathological tumor stage (P < 0.001), and pathological tumor node metastasis (TNM) stage (P = 0.003). Cortactin expression correlated with pathological lymph node stage (P = 0.018), pathological TNM stage (P < 0.001), and degree of differentiation (P < 0.001). There were statistically significant associations between tumor recurrence and VEGF expression (P = 0.023), and cortactin expression (P < 0.001). In multivariate analysis, pathological TNM stage, VEGF expression, and cortactin expression were independent prognostic influence on disease-free survival (P < 0.001, 0.022, and 0.034, respectively).
VEGF and cortactin may be a good biomarker to be applied in clinic to predict the prognosis of patients with curatively resected gastric cancer.
为了研究血管内皮生长因子(VEGF)和桩蛋白表达的临床病理作用,以及它们的表达是否是胃癌根治性切除术后肿瘤复发的独立预测因素。
本研究纳入 128 例胃癌患者。对福尔马林固定石蜡包埋标本进行 VEGF 和桩蛋白染色,并分析染色与临床病理参数及预后能力的相关性。
在 128 例研究患者中,58 例(45.3%)和 71 例(55.5%)患者 VEGF 和桩蛋白表达均为强阳性。VEGF 表达与 Lauren 分类(P < 0.001)、病理肿瘤分期(P < 0.001)和病理肿瘤淋巴结转移(TNM)分期(P = 0.003)相关。桩蛋白表达与病理淋巴结分期(P = 0.018)、病理 TNM 分期(P < 0.001)和分化程度(P < 0.001)相关。肿瘤复发与 VEGF 表达(P = 0.023)和桩蛋白表达(P < 0.001)均存在显著相关性。多因素分析显示,病理 TNM 分期、VEGF 表达和桩蛋白表达是无病生存的独立预后影响因素(P < 0.001、0.022 和 0.034)。
VEGF 和桩蛋白可能是一种很好的生物标志物,可应用于临床预测可切除胃癌患者的预后。