Alzheimer's Disease Clinical Research Centre, Gérontopôle, Toulouse University Hospital, Toulouse, France.
Mov Disord. 2010 Jul 15;25(9):1288-91. doi: 10.1002/mds.23064.
The presence of alien hand syndrome (AHS) is suggestive of the diagnosis of corticobasal degeneration when it develops in a progressive way. Sensory AHS (sAHS) should be distinguished from the motor form described more commonly. The physiopathology of sAHS remains unclear. The aim of this study is to determine cerebral regions involved in sAHS. We compared perfusion single photon emission computer tomography scans of patients with sAHS (n = 3) and without (n = 4). We observed significant decrease of regional cerebral blood flow over the nondominant thalamus in sAHS+ compared to sAHS- patients. This result suggests the involvement of the nondominant thalamus in sAHS.
当出现进行性发展的异己手综合征（AHS）时，提示可能为皮质基底节变性。应将感觉性 AHS（sAHS）与更为常见的运动性 AHS 区分开来。sAHS 的病理生理学仍不清楚。本研究旨在确定 sAHS 涉及的脑区。我们比较了 3 例 sAHS 患者和 4 例无 sAHS 患者的灌注单光子发射计算机断层扫描。与 sAHS-患者相比，sAHS+患者的非优势丘脑区域的局部脑血流明显减少。这一结果提示非优势丘脑参与了 sAHS。
