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多巴胺能脑损伤大鼠模型中膀胱功能障碍的发展。

Development of bladder dysfunction in a rat model of dopaminergic brain lesion.

机构信息

Wake Forest Institute for Regenerative Medicine, Wake Forest University, Winston Salem, North Carolina 27157, USA.

出版信息

Neurourol Urodyn. 2011 Jan;30(1):188-93. doi: 10.1002/nau.20917. Epub 2010 Jun 29.

Abstract

AIMS

Parkinson's disease (PD) is one of the most common neurological disorders causing lower urinary tract dysfunction. We evaluated the temporal development of bladder dysfunction in rat PD model where urodynamic changes were induced by unilateral injection of 6-hydroxydopamine (6-OHDA) into the medial forebrain bundle (MFB).

METHODS

Female Sprague-Dawley rats underwent a unilateral stereotaxic injection of 6-OHDA or vehicle (sham group) into the MFB. Cystometry was performed in conscious animals at 3, 14, and 28 days after the injury. Aged-matched unlesioned rats were used as healthy controls.

RESULTS

Three days after lesion 6-OHDA rats showed higher threshold (TP), maximum pressures (MP), and spontaneous activity (SA) compared to healthy controls. Sham animals exhibited higher TP. After 14 days 6-OHDA rats had also higher micturition frequency, decreased bladder capacity, micturition volume and bladder compliance (Bcom) compared to sham and healthy controls. Sham animals showed lower Bcom and higher MP and SA. After 28 days, 6-OHDA rats exhibited the same changes as those in 14 days, while sham-operated animals showed parameters similar to those in healthy controls.

CONCLUSIONS

These findings suggest that 6-OHDA lesion of the MFB causes bladder dysfunction already after 3 days. A pattern of detrusor overactivity was more clearly defined 14 days after the injection and persisted for 28 days. Cystometry may be a useful tool to study the pathophysiology of bladder dysfunction in PD, and urodynamic parameters may possibly be used to evaluate the effects of therapeutic interventions.

摘要

目的

帕金森病(PD)是最常见的导致下尿路功能障碍的神经退行性疾病之一。我们评估了单侧内侧前脑束(MFB)注射 6-羟多巴胺(6-OHDA)诱导的大鼠 PD 模型中膀胱功能障碍的时间发展。

方法

雌性 Sprague-Dawley 大鼠接受单侧立体定向 MFB 6-OHDA 或载体(假手术组)注射。在损伤后 3、14 和 28 天,对清醒动物进行膀胱测压。未损伤的同龄大鼠用作健康对照。

结果

6-OHDA 大鼠在损伤后 3 天表现出较高的阈值(TP)、最大压力(MP)和自发性活动(SA)。假手术动物表现出较高的 TP。14 天后,6-OHDA 大鼠的排尿频率更高,膀胱容量、排尿量和膀胱顺应性(Bcom)降低,与假手术和健康对照组相比。假手术动物表现出较低的 Bcom 和较高的 MP 和 SA。28 天后,6-OHDA 大鼠表现出与 14 天相同的变化,而假手术动物表现出与健康对照组相似的参数。

结论

这些发现表明,MFB 的 6-OHDA 损伤在损伤后 3 天即可引起膀胱功能障碍。在注射后 14 天,逼尿肌过度活动的模式更为明显,并持续 28 天。膀胱测压术可能是研究 PD 膀胱功能障碍病理生理学的有用工具,并且尿动力学参数可能可用于评估治疗干预的效果。

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